2-Amino-6-ethyl-4(1H)-pyrimidinone(CAS: 5734-66-7)

2-Amino-6-ethyl-4(1H)-pyrimidinone (CAS: 5734-66-7) is a colorless crystalline solid with a molecular weight of approximately 151.19 g/mol. It has a low solubility in water (0.2 g/L at 25°C) and a higher solubility in organic solvents like dimethyl sulfoxide (DMSO). This compound is known for its mild reactivity, particularly in nucleophilic substitution reactions. It is stable under normal laboratory conditions but should be stored in a cool, dry place away from heat sources and oxidizing agents.

2-Amino-6-ethyl-4(1H)-pyrimidinone (CAS: 5734-66-7) can be synthesized through the reaction of ethyl isocyanate with urea. The synthesis involves the addition of ethyl isocyanate to urea in the presence of a base such as sodium hydroxide, followed by heating. This method provides good yields and selectivity, and the reaction is typically carried out at room temperature under air atmosphere. Catalytic amounts of amines or phosphoric acid can enhance the yield and purity of the final product.

2-Amino-6-ethyl-4(1H)-pyrimidinone (CAS: 5734-66-7) finds applications in various industries. In pharmaceuticals, it is used as an intermediate for the synthesis of antiviral and antifungal drugs. It is also utilized in the development of sensors for detecting specific analytes in environmental and biomedical applications. Additionally, it has potential uses in polymer chemistry for the synthesis of functional polymers and in semiconductor technology for the production of certain organic semiconductors.

When handling 2-Amino-6-ethyl-4(1H)-pyrimidinone (CAS: 5734-66-7), it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be stored in a cool, dry place away from heat sources and oxidizing agents. In the event of a spill, it is recommended to use appropriate spill kits and follow proper disposal procedures. Always refer to the Safety Data Sheet (SDS) for detailed information on handling, storage, and emergency procedures. This compound is not considered highly toxic, but it should be treated with caution due to its potential for skin irritation and inhalation hazards.