2,4,6-Trimethylphenol(CAS: 527-60-6)

2,4,6-Trimethylphenol (CAS: 527-60-6) is a white crystalline solid with a molecular weight of approximately 134.21 g/mol. It has a melting point of about 75°C and is poorly soluble in water but readily soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly in esterification and amidation reactions.

2,4,6-Trimethylphenol can be synthesized via the Kolbe-Schmitt reaction, where phenol reacts with methyl chlorides in the presence of a strong base like sodium hydroxide. Another method involves the reduction of 2,4,6-trimethylbenzoyl chloride with lithium aluminum hydride. These processes yield high yields and good selectivity.

2,4,6-Trimethylphenol (CAS: 527-60-6) finds use in a variety of industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly as a precursor for antifungal agents. It also plays a role in the production of polymer additives, sensors, and as a component in some semiconductor materials.

When handling 2,4,6-Trimethylphenol (CAS: 527-60-6), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. It should be stored in a cool, well-ventilated area away from sources of heat and ignition. Fume hoods should be used during handling to minimize inhalation risks. In case of a spill, contact a professional hazmat team and refer to the Safety Data Sheet (SDS) for specific guidelines.