2-(Chloromethyl)-6-methylthieno[2,3-d]pyrimidin-4(1H)-one(CAS: 878699-59-3)

2-(Chloromethyl)-6-methylthieno[2,3-d]pyrimidin-4(1H)-one is a crystalline solid with a molecular weight of approximately 274.01 g/mol. It is slightly soluble in polar solvents like dimethyl sulfoxide (DMSO) and acetone. The compound exhibits good reactivity towards nucleophiles, particularly in the chloromethyl group, making it suitable for various chemical transformations.

2-(Chloromethyl)-6-methylthieno[2,3-d]pyrimidin-4(1H)-one can be synthesized via the condensation of 2-chloroacetyl chloride with 6-methylthieno[2,3-d]pyrimidin-4-one. The reaction is typically catalyzed by a Lewis acid such as aluminum chloride and proceeds with good yields (up to 90%). Selectivity towards the desired product is maintained, making this a reliable route for synthesis.

2-(Chloromethyl)-6-methylthieno[2,3-d]pyrimidin-4(1H)-one finds applications in the pharmaceutical and polymer industries. It is used as an intermediate in the synthesis of medicinal compounds and as a building block in the development of polymeric materials with specific properties such as conductivity and mechanical strength.

When handling 2-(Chloromethyl)-6-methylthieno[2,3-d]pyrimidin-4(1H)-one, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be cleaned up immediately using absorbent materials, and the area should be flushed with water. Refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.