5-Bromo-6-chloro-4-pyrimidinamine(CAS: 663193-80-4)

5-Bromo-6-chloro-4-pyrimidinamine is a crystalline solid with a molecular weight of approximately 244.01 g/mol. It is slightly soluble in water and organic solvents. This compound is known for its low reactivity under normal conditions but can undergo nucleophilic substitution reactions under certain conditions. It is important to store it in a dry, dark place to prevent degradation.

5-Bromo-6-chloro-4-pyrimidinamine is commonly synthesized through the reaction of 4-chloropyrimidine with bromine in the presence of a catalyst like iron(III) chloride. The reaction yields a mixture that can be purified by recrystallization or column chromatography. The yield is typically around 70-80%, and the reaction is highly selective.

5-Bromo-6-chloro-4-pyrimidinamine is used in the pharmaceutical industry for the synthesis of various medicinal compounds. It also finds application in the polymer industry as a precursor for functional polymers. Additionally, it is used in the development of sensors and semiconductors due to its unique chemical properties.

When handling 5-Bromo-6-chloro-4-pyrimidinamine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a fume hood to minimize exposure. Spills should be contained and cleaned up with care, using appropriate absorbents. Refer to the Safety Data Sheet (SDS) for detailed instructions on handling and disposal.