2-Phenyl-1,3-benzoxazole(CAS: 833-50-1)

2-Phenyl-1,3-benzoxazole is a crystalline solid with a molecular weight of 174.22 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. The compound shows good thermal stability and is known for its moderate reactivity, particularly in electrophilic aromatic substitution reactions.

2-Phenyl-1,3-benzoxazole can be synthesized via condensation of phenylglyoxal with phenol in the presence of an acid catalyst, such as sulfuric acid. Alternatively, it can be prepared by the reaction of phenylisoxazole with acetyl chloride. The yield is typically around 70-80%, and the process involves careful control of temperature and reaction time to achieve high product purity.

2-Phenyl-1,3-benzoxazole is widely used in the pharmaceutical industry as a precursor for drug synthesis. It also finds applications in the polymer industry for the production of functional polymers, in the sensor industry for chemical sensing, and in semiconductor manufacturing for photolithography processes.

When handling 2-Phenyl-1,3-benzoxazole, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and residues should be disposed of according to local hazardous waste regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.