5-Bromo-1,2-benzoxazole(CAS: 837392-65-1)

5-Bromo-1,2-benzoxazole (CAS: 837392-65-1) is a crystalline solid with a molecular weight of approximately 204.03 g/mol. It has a melting point of around 210-212°C and is slightly soluble in water. Chemically, it is less reactive compared to other brominated compounds and does not readily undergo substitution reactions under typical conditions. It is stable under normal laboratory conditions but may decompose at elevated temperatures.

5-Bromo-1,2-benzoxazole (CAS: 837392-65-1) is typically synthesized via bromination of 1,2-benzoxazole using N-bromosuccinimide (NBS) in the presence of a suitable organic solvent such as chloroform. The reaction is carried out under UV light, and the product can be isolated by recrystallization from water or ethanol. The yield is generally around 70-80%, and the reaction is highly selective.

5-Bromo-1,2-benzoxazole (CAS: 837392-65-1) is used in various industries, particularly in the pharmaceutical sector for the synthesis of organic compounds and intermediates. It is also utilized in the preparation of polymers, sensors, and semiconductors due to its unique chemical properties. Its bromine substituent provides specific functional groups for further modifications and derivatizations.

When handling 5-Bromo-1,2-benzoxazole (CAS: 837392-65-1), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat to prevent skin and eye contact. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using an appropriate absorbent material, and the area should be flushed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed information on handling and emergency procedures.