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3-Methoxy-N-phenylaniline(CAS: 101-16-6)

3-Methoxy-N-phenylaniline
CAS Number

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Basic Information

Molecular Formula
C13H13NO
Molecular Weight
199.25 g/mol

Physical Properties

Melting Point
71.0 to 74.0 deg-C
Boiling Point
160°C/2mmHg(lit.)
Density
1.1100
Flash Point
132 °C

Chemical Identifiers

SMILES
COC1=CC=CC(=C1)NC2=CC=CC=C2
InChIKey
MKASXAGBWHIGCF-UHFFFAOYSA-N

Database References

MDL Number
MFCD00008383

FAQ

3-Methoxy-N-phenylaniline (CAS: 101-16-6) is a white crystalline solid with a molecular weight of approximately 194.21 g/mol. It has a solubility of about 2.4 g/L in water and is slightly soluble in organic solvents such as ethanol. Chemically, it is relatively stable but can react with strong oxidizing agents. It exhibits a molar absorptivity of 10,000 M^-1 cm^-1 in the UV region, making it useful for analytical chemistry applications.
3-Methoxy-N-phenylaniline (CAS: 101-16-6) is typically synthesized via a condensation reaction between aniline and methanol in the presence of an acid catalyst like sulfuric acid. The reaction is performed at elevated temperatures, often above 100°C, and the yield is generally around 85-90%. The product is purified by recrystallization from ethanol or methanol.
3-Methoxy-N-phenylaniline (CAS: 101-16-6) is used in various industries, including pharmaceuticals for the synthesis of certain drugs, sensors for detecting aromatic compounds, and as a precursor in the production of dyes and pigments. It is also utilized in the preparation of materials for semiconductors and in the development of organic electronics.
When handling 3-Methoxy-N-phenylaniline (CAS: 101-16-6), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed spill procedures and emergency response guidelines.

Safety Notice

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