1-(1,3-Oxazol-4-yl)ethanone(CAS: 859046-10-9)

1-(1,3-Oxazol-4-yl)ethanone is a crystalline solid with a molecular weight of approximately 150.21 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly with nucleophiles, and can undergo various organic reactions such as nucleophilic substitution and condensation reactions.

1-(1,3-Oxazol-4-yl)ethanone can be synthesized via the condensation of 4-chloro-1-ethoxymethylene-1,3-oxazole with sodium ethoxide in ethanol or via the reaction of 4-chlorothiazole with acetaldehyde using a suitable base. The reaction yields a moderately pure product with good selectivity and high yield.

1-(1,3-Oxazol-4-yl)ethanone is used in the pharmaceutical industry for the synthesis of certain drugs, and in the chemical industry for the production of polymers and sensors. It is also utilized in semiconductor manufacturing for specific applications requiring its unique chemical properties.

When handling 1-(1,3-Oxazol-4-yl)ethanone, it is essential to wear protective equipment such as gloves and safety glasses. Work in a well-ventilated area or a fume hood to minimize exposure. Store it in a cool, dry place away from direct sunlight and heat sources. In case of spill, neutralize the spill with an appropriate acid or base before cleaning up, and consult the Safety Data Sheet (SDS) for detailed instructions.