6-Chloro-5-(chloroacetyl)-1,3-dihydro-2H-indol-2-one(CAS: 118307-04-3)

6-Chloro-5-(chloroacetyl)-1,3-dihydro-2H-indol-2-one is a crystalline solid with a molecular weight of approximately 287.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and dichloromethane. The compound is known for its high reactivity, particularly towards nucleophiles. It has a pKa of around 7.5, indicating moderate acidity.

6-Chloro-5-(chloroacetyl)-1,3-dihydro-2H-indol-2-one is typically synthesized via a multi-step process starting from indole. The key steps include chlorination, acetylation, and condensation reactions. The use of thionyl chloride and acetyl chloride as reagents facilitates the chlorination and acetylation steps, respectively. The overall yield is around 50-60%, with high selectivity towards the desired product.

6-Chloro-5-(chloroacetyl)-1,3-dihydro-2H-indol-2-one is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drug candidates. It also finds applications in the sensor industry, where its chemical reactivity allows for the detection of specific analytes. Additionally, it is used in polymer research, particularly in the development of new materials with specific functionalities.

When handling 6-Chloro-5-(chloroacetyl)-1,3-dihydro-2H-indol-2-one, it is essential to use Personal Protective Equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a sealed container to prevent exposure to air and moisture. Storage should be in a cool, dry place away from direct sunlight. In case of spills, use appropriate cleanup methods and ensure proper disposal according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.