1-(2-Thioxo-1,3-thiazolidin-3-yl)ethanone(CAS: 76397-53-0)

1-(2-Thioxo-1,3-thiazolidin-3-yl)ethanone is a white crystalline solid with a molecular weight of 194.28 g/mol. It has a solubility of 1.5 g/L in water and poor solubility in organic solvents. It is moderately reactive, especially towards nucleophiles and reducing agents. It decomposes above 150°C.

1-(2-Thioxo-1,3-thiazolidin-3-yl)ethanone is typically synthesized via the reaction of 2-thioxo-1,3-thiazolidin-3-ylamine with ethyl acetoacetate. The reaction is carried out in the presence of a base such as potassium carbonate, yielding the target compound with good selectivity and yield.

1-(2-Thioxo-1,3-thiazolidin-3-yl)ethanone is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those involving sulfur-containing heterocycles. It is also utilized in the polymer industry as a monomer for synthesizing specific polymers and in the sensor industry for its reactivity towards certain analytes.

Proper personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn when handling 1-(2-Thioxo-1,3-thiazolidin-3-yl)ethanone. Store it in a fume hood to prevent inhalation. In case of spill, use appropriate spill cleanup materials and follow the safety data sheet (SDS) for proper disposal. Avoid contact with skin and eyes and ensure good ventilation in the laboratory area.