Mesitylboronic acid(CAS: 5980-97-2)

Mesitylboronic acid (CAS: 5980-97-2) is a white crystalline solid. Its molecular weight is approximately 165.13 g/mol. It has a very low water solubility but is soluble in organic solvents such as dichloromethane and acetonitrile. Chemically, it exhibits typical reactivity of boronic acids, undergoing nucleophilic substitution reactions under mild conditions.

Mesitylboronic acid is usually synthesized through the reaction of mesityl oxide with boron tribromide in the presence of a base. The process involves the generation of a mesityl borate salt, which then forms mesitylboronic acid upon treatment with water or a protic solvent. The reaction is typically carried out in a glass or Teflon vessel to avoid corrosion.

Mesitylboronic acid finds applications in the pharmaceutical industry for the synthesis of chiral compounds, as well as in the polymer industry for the modification of polymers. It is also used in the semiconductors industry for the preparation of organoboron compounds used as dopants.

When handling mesitylboronic acid, proper personal protective equipment (PPE) including gloves, goggles, and lab coat should be worn. It should be stored in a cool, dry place away from heat sources and incompatible materials. In case of spill, it should be carefully cleaned up using appropriate absorbent materials and disposed of according to hazardous waste regulations. For detailed safety information, refer to the Safety Data Sheet (SDS).