19-Hydroxy-10-deacetylbaccatin III(CAS: 154083-99-5)

19-Hydroxy-10-deacetylbaccatin III (CAS: 154083-99-5) is a semi-crystalline compound with a molecular weight of approximately 470.4 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and ethanol. The compound is relatively stable under normal conditions but may undergo degradation upon exposure to light and moisture. It is used in synthetic pathways for taxol production and exhibits limited chemical reactivity under standard conditions.

19-Hydroxy-10-deacetylbaccatin III (CAS: 154083-99-5) is typically synthesized via a series of enzymatic reactions followed by chemical modifications. Common methods involve the use of enzymes like acetyltransferases and hydroxylases in a biocatalytic pathway, with subsequent acid or base-catalyzed reactions to deacetylate and hydroxylate the baccatin III precursor. The yield is generally around 70-80% with good selectivity for the desired product.

19-Hydroxy-10-deacetylbaccatin III (CAS: 154083-99-5) is primarily used in the pharmaceutical industry for the production of taxol, an important anti-cancer drug. It is also explored for applications in the field of polymer chemistry, where it can be used as a monomer or functional group for material modification. Additionally, it has potential uses in developing advanced sensors and semiconductors due to its chemical properties.

When handling 19-Hydroxy-10-deacetylbaccatin III (CAS: 154083-99-5), appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat should be used to minimize skin and eye contact. Work should be performed in a well-ventilated fume hood to avoid inhalation. In case of a spill, it is recommended to use absorbent material and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal guidelines.