(4-Bromo-phenyl)-(3-chloro-1H-indol-7-yl)-methanone(CAS: 91714-51-1)

(4-Bromo-phenyl)-(3-chloro-1H-indol-7-yl)-methanone is a crystalline solid with a molecular weight of approximately 395.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and dichloromethane. The compound is moderately reactive, showing basic properties due to its indole ring. It is stable under normal laboratory conditions but should be stored in a cool, dry place away from direct sunlight.

(4-Bromo-phenyl)-(3-chloro-1H-indol-7-yl)-methanone can be synthesized through a multi-step reaction starting from bromobenzene and 3-chloro-1H-indole. The process involves the formation of the bromophenyl group followed by the coupling with the indole ring. Common catalysts include palladium-based catalysts, and the reaction is typically carried out under microwave conditions to improve yield and selectivity. The overall yield is around 75-85%.

(4-Bromo-phenyl)-(3-chloro-1H-indol-7-yl)-methanone finds application in the pharmaceutical industry, particularly in the development of new drug candidates. It can also be used in the synthesis of certain types of polymers and sensors. Due to its structural complexity, it is less commonly used in semiconductor applications but may find niche uses in advanced materials research.

When handling (4-Bromo-phenyl)-(3-chloro-1H-indol-7-yl)-methanone, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a sealed container and handled in a well-ventilated area or a fume hood. In case of a spill, it should be handled according to the safety data sheet (SDS) and cleaned up using appropriate absorbents. Always ensure that the compound is disposed of in an environmentally safe manner following local regulations and guidelines.