4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine(CAS: 744209-63-0)

4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine is a crystalline solid with a molecular weight of approximately 310.18 g/mol. It is slightly soluble in water but soluble in organic solvents like DMSO and DMF. This compound exhibits moderate reactivity, particularly under basic conditions. It is stable under normal storage conditions but should be protected from moisture and heat.

4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine can be synthesized via the reaction of 4-chloropyrrolo[2,3-b]pyridine with phenylsulfonyl chloride in the presence of a base, such as triethylamine. The yield is typically around 70-80%, and the reaction is carried out in an inert solvent like dichloromethane. The reaction is selective and proceeds under mild conditions.

4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those targeting receptor pathways. It is also used in the semiconductor industry for its electronic properties and in the polymer industry for its potential as a functional monomer.

When handling 4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or fume hood to avoid inhalation. In the event of a spill, it should be carefully cleaned up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.