(4-Methoxy-5-pyrimidinyl)boronic acid(CAS: 909187-37-7)

(4-Methoxy-5-pyrimidinyl)boronic acid is a crystalline solid with a molecular weight of approximately 211.13 g/mol. It is slightly soluble in water and more soluble in organic solvents. Chemically, it is highly reactive towards nucleophiles and can participate in boronate ester formation and other organoboron reactions. It has a melting point around 215-217°C.

(4-Methoxy-5-pyrimidinyl)boronic acid is synthesized through the reaction of 4-methoxypyrimidine with boron tribromide, followed by treatment with sodium hydroxide. The yield is typically around 80%, and the reaction is carried out under anhydrous conditions to avoid side reactions.

(4-Methoxy-5-pyrimidinyl)boronic acid is used in the pharmaceutical industry for the synthesis of various drug candidates, particularly in asymmetric synthesis. It is also utilized in the polymer industry for the development of functional polymers, and in the sensor industry for designing chemically sensitive materials.

When handling (4-Methoxy-5-pyrimidinyl)boronic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves and goggles. The substance should be stored in a well-ventilated area, and work should be conducted in a fume hood. In case of a spill, neutralize the acid with a base and dispose of the material according to the Material Safety Data Sheet (MSDS) guidelines.