2,6-Dichloro-4-phenylquinoline(CAS: 10352-30-4)

2,6-Dichloro-4-phenylquinoline is a crystalline solid with a molecular weight of approximately 265.06 g/mol. It has low water solubility and high solubility in organic solvents such as acetone and dimethylformamide. It is slightly reactive, particularly towards strong bases and can form complexes with certain metal ions. Its stability under normal conditions makes it suitable for laboratory applications.

2,6-Dichloro-4-phenylquinoline is typically synthesized via the condensation of 2,6-dichloroquinoline with phenylmagnesium bromide. The reaction requires use of anhydrous conditions and is catalyzed by tin(II) chloride. The yield is around 70-80%, and the product is purified by recrystallization from ethanol or acetone.

2,6-Dichloro-4-phenylquinoline is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in organic semiconductor materials for electronic devices. Its properties make it useful in sensor technology and as a precursor in polymer chemistry.

When handling 2,6-Dichloro-4-phenylquinoline, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood. In case of spills, avoid direct contact and clean up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.