Synthesis of completely solvent-free biomedical waterborne polyurethane with excellent mechanical property retention and satisfactory water absorption
Literature Information
Ao Zhen, Guanyu Zhang, Ao Wang, Feng Luo, Jiehua Li, Hong Tan, Zhen Li
In the physiological environment, implanted biomaterials require hydrophilicity for biocompatibility and mechanical retention for deformation resistance; however, synthesizing waterborne polyurethane (WPU) materials that exhibit both properties remain a challenge. Herein, we report a WPU material crosslinked with trifunctional polycaprolactone synthesized using the microemulsion method under completely solvent-free conditions, exhibiting high retention of mechanical properties and satisfactory water absorption rates. The hydrophobic polycaprolactone triol serves a dual role: it acts as a co-stabilizer, protecting the isocyanate (–NCO) groups inside the colloid from hydrolysis during microemulsion and enhances the material's resilience to mechanical property degradation under wet conditions. The water absorption test and the retention of mechanical properties in the wet and dry states demonstrated that both the films and scaffolds retained their excellent mechanical properties under high water absorption conditions, making the material suitable for applications in biological organisms. In addition, the hemolysis rate test, degradation solution cytotoxicity, and cell death staining preliminarily demonstrated that the material exhibited excellent biocompatibility. This synthesis process and structural design allowed WPU to exhibit mechanical retention and water absorption under wet conditions. This WPU material was synthesized using a completely solvent-free microemulsion process (MWPU) and has broad application potential in the biomedical field.
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DOI: 10.1039/A708951A
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Journal of Materials Chemistry A

Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. The journals have a strong history of publishing quality reports of interest to interdisciplinary communities and providing an efficient and rigorous service through peer review and publication. The journals are led by an international team of Editors-in-Chief and Associate Editors who are all active researchers in their fields. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C. More than one Journal of Materials Chemistry journal may be suitable for certain fields and researchers are encouraged to submit their paper to the journal that they feel best fits for their particular article. Example topic areas within the scope of Journal of Materials Chemistry A are listed below. This list is neither exhaustive nor exclusive. Artificial photosynthesis Batteries Carbon dioxide conversion Catalysis Fuel cells Gas capture/separation/storage Green/sustainable materials Hydrogen generation Hydrogen storage Photocatalysis Photovoltaics Self-cleaning materials Self-healing materials Sensors Supercapacitors Thermoelectrics Water splitting Water treatment










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