A novel synthesis of dihydrofuranyl alcohols through cascade reactions of 1,3-diketones with α,β-unsaturated epoxides
Literature Information
Publication Date
2023-10-09
DOI
10.1039/D3QO01309J
Impact Factor
5.281
Authors
Chengyu Yu, Penji Yan, Hai Song, Hucheng Shi, Yangfei Wei, Zhengen Song, Xin Jia
View Original
Abstract
A novel synthesis of highly functionalized dihydrofuranyl alcohols has been developed through a tandem process including Michael addition of α,β-unsaturated epoxides with 1,3-diketones, an aldol reaction, a retro-aldol reaction, enolization, and epoxide ring-opening. These reactions proceeded smoothly in the presence of a PTC, affording a variety of dihydrofuranyl alcohols in good yields of up to 97.1%.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
2-(4,4-Difluorobutyl)-1H-isoindole-1,3(2H)-dione
CAS Number:
1265341-14-7
Molecular Formula:
C12H11F2NO2
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