Synthesis of 2-amidoindenone derivatives through an ynamide carbosilylation/Houben–Hoesch cyclization 2-step sequence
Literature Information
Pierre Hansjacob, Célia Schwoerer, Frédéric R. Leroux, Morgan Donnard
Herein we report the efficient and selective two-step synthesis of various 3-silyl-2-amidoindenones from easily accessible ynamides. This sequence involves a regio- and stereo-selective silylcyanation followed by a Houben–Hoesch type cyclization. Thanks to post-transformations, various 3-substituted 2-amidoindenones could be obtained.
Related Literature
Enhanced π⋯π interactions in α,β-unsaturated carbonyls
Lisa D. Harris, James A. Platts, Nicholas C. O. Tomkinson
DOI: 10.1039/B210497K
Palladium-catalyzed cascade carboesterification of norbornene with alkynes
Can Li, Jianxiao Li, Huanfeng Jiang
DOI: 10.1039/C8OB01799A
Mechanism of the oxidation of aromatic sulfides catalysed by a water soluble iron porphyrin
Enrico Baciocchi, Maria Francesca Gerini, Osvaldo Lanzalunga, Andrea Lapi, Maria Grazia Lo Piparo
DOI: 10.1039/B209004J
Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups
Hiromasa Kurosaki, Hisami Yasuzawa, Yoshihiro Yamaguchi, Wanchun Jin, Yoshichika Arakawa, Masafumi Goto
DOI: 10.1039/B209086D
Recent advances in the synthesis of azaphenalene alkaloids: first enantioselective approaches
Sílvia Alujas-Burgos, Pau Bayón, Marta Figueredo
DOI: 10.1039/C8OB01443D
Nitrile biotransformations for the synthesis of enantiomerically enriched Baylis–Hillman adducts
Mei-Xiang Wang, Yan Wu
DOI: 10.1039/B209791E
Base-catalyzed selective esterification of alcohols with unactivated esters
Chunyan Zhang, Guoying Zhang, Shizhong Luo, Chunfu Wang, Huiping Li
DOI: 10.1039/C8OB02411A
Molecular recognition in the gas phase ligand switching reactions of the proton bound dimer of sarcosine and glycylglycine.‡
Richard A. J. O'Hair, Ana K. Vrkic
DOI: 10.1039/B209848B
The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs
Michelle A. C. Reed, Michael Schweizer, Anna E. Szafranska, Chris Arthur, Thomas P. Nicholson, Russell J. Cox, John Crosby, Matthew P. Crump, Thomas J. Simpson
DOI: 10.1039/B208941F
Synthesis of a tweezer-like bis(arylthiaalkoxy)calix[4]arene as a cation sensor for ion-selective electrodes: an investigation of the influence of neighboring halogen atoms on cation selectivity‡
Xianshun Zeng, Langxing Chen, Xuebing Leng, Fengbo Xu, Qinshan Li, Xiwen He, Wenqin Zhang, Zheng-Zhi Zhang
DOI: 10.1039/B211381C
You might also like
How should 2-Methylbenzene-1,4-diamine dihydrochloride (CAS: 615-45-2) be stored?
2-Methylbenzene-1,4-diamine dihydrochloride (CAS: 615-45-2) should be stored in ...
Is (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrobromide (CAS: 132747-20-7) safe?
(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrobromide is generally considered sa...
What industries use (6-Chloropyridazin-3-YL)methanamine (CAS: 871826-15-2)?
(6-Chloropyridazin-3-YL)methanamine finds applications in the pharmaceutical ind...
What are the main uses of 2-Fluoro-3-methylphenol (CAS: 77772-72-6)?
2-Fluoro-3-methylphenol is primarily used in the synthesis of pharmaceuticals, p...
What precautions should be taken when handling 3-Methoxy-4-nitrobenzonitrile (CAS: 177476-75-4)?
When handling 3-Methoxy-4-nitrobenzonitrile, it is important to wear appropriate...
What precautions should be taken when handling 1,3-Oxazolo[4,5-b]pyridine-2(3H)-thione (CAS: 211949-57-4)?
When handling 1,3-Oxazolo[4,5-b]pyridine-2(3H)-thione (CAS: 211949-57-4), it is ...
What regulatory guidelines apply to 4-Ethynylbenzamide (CAS: 90347-86-7)?
4-Ethynylbenzamide (CAS: 90347-86-7) falls under various regulatory guidelines i...
What are the main uses of 3-(2-Ethylphenyl)-2-thioxo-4-imidazolidinone (CAS: 186822-57-1)?
3-(2-Ethylphenyl)-2-thioxo-4-imidazolidinone is primarily used as an intermediat...
What is (2-Fluoro-6-methoxyphenyl)acetic acid (CAS: 500912-19-6)?
(2-Fluoro-6-methoxyphenyl)acetic acid, also known as 4-fluoro-3-methoxybenzoic a...
What is the market or research trend for 2-[4-(Hydroxymethyl)phenoxy]ethanol (CAS: 102196-18-9)?
Market trends for 2-[4-(Hydroxymethyl)phenoxy]ethanol (CAS: 102196-18-9) indicat...
Source Journal
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.











![[1-(5-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]methanol structure [1-(5-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]methanol structure](https://static.chemtradehub.com/structs/143/1439822-99-7-6cc9.webp)

![(1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid structure (1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid structure](https://static.chemtradehub.com/structs/865/865689-24-3-5fef.webp)
