Harnessing the power of a photoinitiated thiol–ene “click” reaction for the efficient synthesis of S-lipidated collagen model peptide amphiphiles
Literature Information
Sujay Prabakar, Wenkai Zhang
A photoinitiated thiol–ene “click” reaction was used to synthesize S-lipidated collagen model peptide amphiphiles. Use of 2-iminothiolane provided an epimerization-free thiol handle required for thiol–ene based incorporation of lipid moieties onto collagen-based peptide sequences. This approach not only led to improvements in the triple helical characteristics of the resulting collagen model peptides but also increased the aqueous solubility of the peptide amphiphiles. As a result, this methodology holds significant potential for the design and advancement of functional peptide amphiphiles, offering enhanced capabilities across a wide range of applications.
Related Literature
Intramolecular charge transfer with N-benzoylaminonaphthalenes. 1-Aminonaphthaleneversus2-aminonaphthalene as electron donors
Xuan Zhang, Chun-Hua Liu, Li-Hong Liu, Lin Guo, Chao-Jie Wang, Yun-Bao Jiang
DOI: 10.1039/B210106H
Characterization of binary solvent mixtures: the water–acetonitrile mixture
Francisco García-Blanco
DOI: 10.1039/B210405A
A convenient stereoselective access to novel 1,2,4-triazepan-3-ones/thiones via reduction or reductive alkylation of 7-membered cyclic semicarbazones and thiosemicarbazones
Anastasia A. Fesenko, Mikhail S. Grigoriev, Anatoly D. Shutalev
DOI: 10.1039/C8OB01766B
DNA recognition by the anthracycline antibiotic respinomycin D: NMR structure of the intercalation complex with d(AGACGTCT)2
Mark S. Searle, Allister J. Maynard, Huw E. L. Williams
DOI: 10.1039/B208622K
Synthesis and Suzuki–Miyaura cross coupling reactions for post-synthetic modification of a tetrabromo-anthracenyl porphyrin
Joffrey Pijeat, Yannick J. Dappe, Pierre Thuéry, Stéphane Campidelli
DOI: 10.1039/C8OB02150C
Gas phase chemistry of the 2-tert-butyl-3-phenylphosphirenylium cation: novel onium ions by nucleophilic attack at phosphorus and de novo P-spiro bicyclic phosphonium ions via [4 + 2+] cycloaddition with dienes
Adão A. Sabino, Marcos N. Eberlin, Luis Alberto B. Moraes, Kenneth K. Laali
DOI: 10.1039/B209696J
Tuning the keto equilibrium in 4-substituted dipicolinic acid derivatives
Anne-Sophie Chauvin, Sandrine Gras, Jean-Claude G. Bünzli
DOI: 10.1039/B211267C
Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum
Yi Guo, Na Zhang, Weiguang Sun, Xueyan Duan, Qing Zhang, Qun Zhou, Chunmei Chen, Hucheng Zhu, Zengwei Luo, Junjun Liu, Xiao-Nian Li, Yongbo Xue, Yonghui Zhang
DOI: 10.1039/C8OB02067A
Studies toward the synthesis of strevertenes A and G: stereoselective construction of C1–C19 segments of the molecules
Tapan Kumar Kuilya, Subhendu Das, Dhiman Saha, Rajib Kumar Goswami
DOI: 10.1039/C8OB01754A
Palladium-catalyzed cascade carboesterification of norbornene with alkynes
Can Li, Jianxiao Li, Huanfeng Jiang
DOI: 10.1039/C8OB01799A
You might also like
How should 2-Methylbenzene-1,4-diamine dihydrochloride (CAS: 615-45-2) be stored?
2-Methylbenzene-1,4-diamine dihydrochloride (CAS: 615-45-2) should be stored in ...
Is (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrobromide (CAS: 132747-20-7) safe?
(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrobromide is generally considered sa...
What industries use (6-Chloropyridazin-3-YL)methanamine (CAS: 871826-15-2)?
(6-Chloropyridazin-3-YL)methanamine finds applications in the pharmaceutical ind...
What are the main uses of 2-Fluoro-3-methylphenol (CAS: 77772-72-6)?
2-Fluoro-3-methylphenol is primarily used in the synthesis of pharmaceuticals, p...
What precautions should be taken when handling 3-Methoxy-4-nitrobenzonitrile (CAS: 177476-75-4)?
When handling 3-Methoxy-4-nitrobenzonitrile, it is important to wear appropriate...
What precautions should be taken when handling 1,3-Oxazolo[4,5-b]pyridine-2(3H)-thione (CAS: 211949-57-4)?
When handling 1,3-Oxazolo[4,5-b]pyridine-2(3H)-thione (CAS: 211949-57-4), it is ...
What regulatory guidelines apply to 4-Ethynylbenzamide (CAS: 90347-86-7)?
4-Ethynylbenzamide (CAS: 90347-86-7) falls under various regulatory guidelines i...
What are the main uses of 3-(2-Ethylphenyl)-2-thioxo-4-imidazolidinone (CAS: 186822-57-1)?
3-(2-Ethylphenyl)-2-thioxo-4-imidazolidinone is primarily used as an intermediat...
What is (2-Fluoro-6-methoxyphenyl)acetic acid (CAS: 500912-19-6)?
(2-Fluoro-6-methoxyphenyl)acetic acid, also known as 4-fluoro-3-methoxybenzoic a...
What is the market or research trend for 2-[4-(Hydroxymethyl)phenoxy]ethanol (CAS: 102196-18-9)?
Market trends for 2-[4-(Hydroxymethyl)phenoxy]ethanol (CAS: 102196-18-9) indicat...
Source Journal
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.










![trans-2-{[(Tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid structure trans-2-{[(Tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid structure](https://static.chemtradehub.com/structs/951/951173-25-4-27cd.webp)
![(1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid structure (1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid structure](https://static.chemtradehub.com/structs/865/865689-24-3-5fef.webp)
![1H-Imidazo[4,5-c]pyridine-7-carboxylic acid structure 1H-Imidazo[4,5-c]pyridine-7-carboxylic acid structure](https://static.chemtradehub.com/structs/123/1234616-39-7-1344.webp)

