CRISPR-Cas12a-enhanced mass spectrometric DNA nanomachine for HPV-16 detection in human serum
Literature Information
Yueli Hu, Liwei Liu, Chaoqun Wang, Jing Zhou, Rui Liu
Cervical cancer is the second most harmful cancer to women, while human papillomavirus (HPV)-16 is the main cause of cervical cancer. Early virus screening can reduce the risk of death, but is sometimes challenged by the low concentration and complicated matrix in physiological samples such as human serum. Herein, we report a CRISPR-Cas12a-enhanced mass spectrometric 3D DNA nanomachine for HPV-16 detection in human serum. Thanks to the high sensitivity of the CRISPR-Cas12a-enhanced 3D DNA nanomachine, and the high matrix-tolerance of elemental mass spectrometry, the proposed method was successfully applied for direct human serum analysis with a low detection limit of 1.2 pM.
Related Literature
Computational study of oxygen atom (3P and 1D) reactions with CF3CN
Jingyu Sun, Yizhen Tang, Xiujuan Jia, Fang Wang, Yunju Zhang, ShuWei Tang, Fengdi Wang, Yingfei Chang, Yongji Lu, Xiumei Pan, Jingping Zhang, Rongshun Wang
DOI: 10.1039/C004284F
14NHYSCORE investigation of the H-cluster of [FeFe] hydrogenase: evidence for a nitrogen in the dithiol bridge
Alexey Silakov, Brian Wenk, Eduard Reijerse, Wolfgang Lubitz
DOI: 10.1039/B905841A
A new cyanoaromatic photosensitizer vs.9,10-dicyanoanthracene: systematic comparison of the photophysical properties
Sylvie Blanc, Thierry Pigot, Cyril Cugnet, Ross Brown, Sylvie Lacombe
DOI: 10.1039/C002705G
Structural and hygroscopic changes of soot during heterogeneous reaction with O3
Yongchun Liu, Chang Liu, Jinzhu Ma, Qingxin Ma, Hong He
DOI: 10.1039/C0CP00402B
Dynamic nuclear polarization coupling factors calculated from molecular dynamics simulations of a nitroxide radical in water
Deniz Sezer, M. J. Prandolini, Thomas F. Prisner
DOI: 10.1039/B905709A
Double layer in room temperature ionic liquids: influence of temperature and ionic size on the differential capacitance and electrocapillary curves
Renata Costa, Carlos M. Pereira, Fernando Silva
DOI: 10.1039/C003920A
Solvent-shift Monte Carlo: a cluster algorithm for solvated systems
Christopher Adam Hixson, James P. Benigni, David J. Earl
DOI: 10.1039/B905254B
Proton mobility through a second order phase transition: theoretical and experimental study of LaNbO4
Harald Fjeld, Kazuaki Toyoura, Reidar Haugsrud, Truls Norby
DOI: 10.1039/C002851G
The role of mass transport pathway in wormholelike mesoporous carbon for supercapacitors
Yeru Liang, Fengxue Liang, Zhenghui Li, Fangyu Yan, Siyu Li
DOI: 10.1039/C003213A
Density functional triple jumping
Jia Deng, Andrew T. B. Gilbert, Peter M. W. Gill
DOI: 10.1039/C0CP00242A
You might also like
What precautions should be taken when handling 2-Chloro-1,2-bis(4-methylphenyl)ethanone (CAS: 71193-32-3)?
When handling 2-Chloro-1,2-bis(4-methylphenyl)ethanone (CAS: 71193-32-3), it is ...
What industries use 4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)benzenesulfonyl chloride (CAS: 224789-26-8)?
4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl...
How should Methyl 3-Oxo-4-Androsten-17-Carboxylate (CAS: 2681-55-2) be stored?
Methyl 3-Oxo-4-Androsten-17-Carboxylate (CAS: 2681-55-2) should be stored in a c...
What are the main uses of (R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid (CAS: 909725-61-7)?
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid is primarily used i...
What regulatory guidelines apply to 2-Methyl-2-propanyl 3-amino-3-carbamoyl-1-azetidinecarboxylate (CAS: 1254120-14-3)?
2-Methyl-2-propanyl 3-amino-3-carbamoyl-1-azetidinecarboxylate (CAS: 1254120-14-...
Are there alternatives to (E)-4-(tert-Butoxy)-4-oxobut-2-enoic acid (CAS: 135355-96-3) in synthesis?
There are alternative reagents that can be used in synthesis instead of (E)-4-(t...
What are the physical and chemical properties of [2-(3-Chlorophenyl)-1,3-thiazol-4-yl]methanol (CAS: 121202-20-8)?
[2-(3-Chlorophenyl)-1,3-thiazol-4-yl]methanol (CAS: 121202-20-8) is a crystallin...
What is the market or research trend for Methyl (2S)-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]{[(4-methylphenyl)sulfonyl]oxy}acetate (CAS: 166249-17-8)?
The market and research trends for Methyl (2S)-[(4S)-2,2-dimethyl-1,3-dioxolan-4...
What is the market or research trend for 1-Bromo-2-isocyanatoethane (CAS: 42865-19-0)?
The market for 1-Bromo-2-isocyanatoethane (CAS: 42865-19-0) is driven by its use...
What are the main uses of 4-Nitro-D-phenylalanine hydrochloride (CAS: 147065-06-3)?
4-Nitro-D-phenylalanine hydrochloride (CAS: 147065-06-3) is primarily used in re...
Source Journal
Chemical Communications

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry











![4-[2-(Trichlorosilyl)ethyl]benzenesulfonyl chloride structure 4-[2-(Trichlorosilyl)ethyl]benzenesulfonyl chloride structure](https://static.chemtradehub.com/structs/797/79793-00-3-de16.webp)


