Pd/Brønsted acid catalysed intramolecular N-allylation of indoles and pyrroles with alkynes for the synthesis of N-fused heterocycles

Literature Information

Publication Date 2023-12-06
DOI 10.1039/D3CC05023H
Impact Factor 6.222
Authors

Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi


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Abstract

We, herein, report a Pd(0) and Brønsted acid-catalyzed redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes for the synthesis of biologically important imidazolidinone-fused N-heterocycles. The allylation is completely atom-economical and is applicable to a wide range of substrates. The methodology eliminates the use of a leaving group or an oxidizing agent, often employed for the allylation of nucleophiles. To the best of our knowledge, N-allylation of indoles and pyrroles with alkynes has not been reported to date.

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Front cover

Cover

DOI: 10.1039/D0PY90082F

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