Peptide coupling using recyclable bicyclic benziodazolone
Literature Information
Daigo Uehara, Sota Adachi, Akira Tsubouchi, Yohei Okada, Viktor V. Zhdankin, Akira Yoshimura, Akio Saito
We report a greener peptide coupling using bicyclic benziodazolone and triarylphosphine as coupling reagents. Bicyclic benziodazolone also works as a base and can be recovered as the corresponding iodine(I) compound after use, which can be converted to the original iodine(III) reagent by electrolytic oxidation.
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