A mild and efficient procedure for α-bromination of ketones using N-bromosuccinimide catalysed by ammonium acetate
Literature Information
Kiyoshi Tanemura, Tsuneo Suzuki, Yoko Nishida, Koko Satsumabayashi, Takaaki Horaguchi
Cyclic ketones reacted with N-bromosuccinimide (NBS) catalysed by NH4OAc in Et2O at 25 °C to give the corresponding α-brominated ketones in good yields, while acyclic ketones were efficiently brominated in CCl4 at 80 °C.
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