Solvation rules: aromatic interactions outcompete cation–π interactions in synthetic host–guest complexes in water
Literature Information
Gloria Tobajas-Curiel, Jeremy K. M. Sanders, Christopher A. Hunter
Chemical double mutant cycles were used to measure the interaction of a N-methyl pyridinium cation with a π-box in a calix[4]pyrrole receptor. Although the cation–π interaction is attractive (−11 kJ mol−1), it is 7 kJ mol−1 less favourable than the corresponding aromatic interaction with the isosteric but uncharged tolyl group.
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