Microwave-assisted chemoselective transamidation of secondary amides by selective N–C(O) bond cleavage under catalyst, additive and solvent-free conditions
Literature Information
Publication Date
2023-11-09
DOI
10.1039/D3CC04128J
Impact Factor
6.222
Authors
Vishal Singh, Khushbu Rajput, Ankush Mishra, Sundaram Singh, Vandana Srivastava
View Original
Abstract
A microwave-assisted, highly chemoselective protocol has been developed for the transamidation of tert-butyloxycarbonyl (Boc) activated secondary carboxamides with amines. Under non-conventional microwave techniques, the reactions were achieved under catalyst, additive, promoter and solvent-free conditions. The transamidation of a structurally diverse set of amides and amines was accomplished in good to excellent yields. The salient features of the developed methodology include a simple operation, broad substrate scope, functional group tolerance, practicality, and the scalability.
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Chemical Communications
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