Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window

Literature Information

Publication Date 2023-11-01
DOI 10.1039/D3CC04082H
Impact Factor 6.222
Authors

Ying Du, Guangyu Chu, Rui Yu, Rui Cui, Yuling Wang, Yiyong Mai, Ming Guan, Fugui Xu, Yongfeng Zhou


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Abstract

A Zinc phthalocyanine-based (ZnPc–PA) polymeric micelle around 70 nm and with dual-modal PTT/PDT functions for non-antibiotic bacteria eradication was developed. It showed an excellent bacterial killing efficiency of 95.2% and 96.7% in vitro against Methicillin-resistant Staphylococcus aureus (MRSA) and its biofilm, respectively. Furthermore, the in vivo experiments proved its great potential for implant-associated infection (IAI).

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