Development of a gold nanoparticle-based lateral-flow strip for the detection of cannabidiol in functional beverages
Literature Information
Publication Date
2023-02-21
DOI
10.1039/D3AN00084B
Impact Factor
4.616
Authors
Shuai Lv, Xinxin Xu, Lingling Guo, Liguang Xu, Liqiang Liu, Chuanlai Xu
View Original
Abstract
Cannabidiol (CBD), the most predominant cannabinoid, may cause addiction and liver damage. In this study, we synthesized a CBD hapten containing the carboxyl group of the spacer arm by derivatizing CBD. A highly specific and sensitive monoclonal antibody (mAb) was prepared with a half-maximal inhibitory concentration of 2.03 ng mL−1 and a limit of detection of 0.32 ng mL−1. MAb was highly specific for CBD. We developed an immunochromatographic assay (ICA) for the detection of CBD in functional beverages with a visible limit of detection of 100 ng mL−1 and a cut-off of 1000 ng mL−1. Compared with HPLC, ICA is more efficient and accurate and can be used for the rapid on-site detection of CBD in samples.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
4-Methyl-3-morpholinecarboxylic acid hydrochloride (1:1)
CAS Number:
1240518-90-4
Molecular Formula:
C6H12ClNO3
![N-[2-(4-Hydroxyphenoxy)-4-nitrophenyl]methanesulfonamide structure](https://static.chemtradehub.com/structs/109/109032-22-6-7c88.webp "N-[2-(4-Hydroxyphenoxy)-4-nitrophenyl]methanesulfonamide structure")
N-[2-(4-Hydroxyphenoxy)-4-nitrophenyl]methanesulfonamide
CAS Number:
109032-22-6
Molecular Formula:
C13H12N2O6S
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