A colorimetric chemical tongue detects and distinguishes between multiple analytes
Literature Information
Publication Date
2022-10-17
DOI
10.1039/D2AN01615J
Impact Factor
4.616
Authors
Francis Buan Hong Lim, Tingjun Lei, Gabriella Fernandez, Nicole Lopez, Andre-Lorenz Chu, Allan Valiente, Abhignyan Nagesetti, Andy Nelson, Kerstin Schmidt, Ta Chen Chang, Obdulio Piloto
View Original
Abstract
The rate-limiting step for diagnostics development is the discovery and validation of biomarker analytes. We describe a new analyte-agnostic and label-free approach based on colorimetric reactions involving type I polymerization photoinitiators. We demonstrate that a chemically diverse array of hydrogels embedded with cleaved type I photoinitiators could act as microreactors, undergoing colorimetric reactions with bound analytes. The colorimetric signatures produced were visually distinctive and readable with a flatbed document scanner. Signatures of a broad range of sample types were accurately differentiated by unsupervised clustering without knowledge of any analytes bound to the array. The principles described have the potential to enable scalable and cost-effective analysis of complex samples.
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