Construction of quaternary carbon centers by KOtBu-catalyzed α-homoallylic alkylation of lactams with 1,3-dienes
Literature Information
Publication Date
2022-02-02
DOI
10.1039/D1QO01927A
Impact Factor
5.281
Authors
Shang Wang, Yunfei Xiang, Tiantian Chen, Xiang Wu, Dong Xing
View Original
Abstract
We report a KOtBu-catalyzed α-homoallylic alkylation of lactams with 1,3-dienes. With this transition metal-free and atom-economical protocol, a variety of α-homoallylic alkylated lactams bearing α-quaternary carbon centers were formed in a 2,1-addition manner with excellent regioselectivity. A cation–π interaction between the in situ-generated potassium enolate and the diene is proposed to play a key role in accelerating this transformation.
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Organic Chemistry Frontiers
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