The first N-ligand assisted Pd catalyzed asymmetric synthesis of 3-arylsuccinimides as novel antifungal leads
Literature Information
Publication Date
2021-11-22
DOI
10.1039/D1QO01510A
Impact Factor
5.281
Authors
Jixing Lai, Juan Yang, Chen Yang, René Csuk, Baoan Song, Shengkun Li
View Original
Abstract
The first palladium/chiral nitrogenous ligand-catalyzed enantioselective addition of aryl boronic acids to various maleimides was reported. This protocol features mild conditions combined with good functional group tolerance. The resultant 3-arylsuccinimides were shown to be novel chiral antifungal leads and inspired the discovery of novel ligands to address the challenging issues of this transformation.
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Organic Chemistry Frontiers
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