Metal-free electrochemical synthesis of α-ketoamides via decarboxylative coupling of α-keto acids with isocyanides and water
Literature Information
Publication Date
2021-10-26
DOI
10.1039/D1QO01351C
Impact Factor
5.281
Authors
Feng Zhao, Na Meng, Ting Sun, Jiangwei Wen, Xiaohui Zhao
View Original
Abstract
A mild and environmentally benign electrochemical strategy has been developed for the synthesis of α-ketoamides via a decarboxylative coupling reaction of α-keto acids with isocyanides and water. The present reaction was efficiently conducted under constant current electrolysis using n-Bu4NI as the electrolyte in an undivided cell. A series of α-ketoamides could be conveniently and rapidly constructed at room temperature in the absence of transition metal catalysts and external oxidants. Mechanistic studies suggested that water not only served as a starting material to construct α-ketoamides, but also played an important role in promoting the electrochemical redox of α-keto acids.
Recommended Journals
Journal of Physics and Chemistry of Solids
Pharmacological Reviews
Helvetica Chimica Acta
Israel Journal of Chemistry
Planta Medica
Proceedings of the National Academy of Sciences of the United States of America
Kinetics and Catalysis
Russian Chemical Reviews
Organic Preparations and Procedures International
Journal of Catalysis
Related Literature
Revisiting the Volmer–Heyrovský mechanism of hydrogen evolution on a nitrogen doped carbon nanotube: constrained molecular dynamics versus the nudged elastic band method
Rasmus Kronberg, Heikki Lappalainen, Kari Laasonen
2020-01-24
Paper
DOI: 10.1039/C9CP06474E
A computational exploration of the 1D TiS2(en) nanostructure for lithium ion batteries
Chun-Hao Huang, Elise Y. Li
2020-03-31
Paper
DOI: 10.1039/C9CP04675E
Sulfur hydrogen bonding and internal dynamics in the monohydrates of thenyl mercaptan and thenyl alcohol
Marcos Juanes, Rizalina Tama Saragi, Ruth Pinacho, José E. Rubio, Alberto Lesarri
2020-05-12
Paper
DOI: 10.1039/D0CP01706J
Anisotropic hydrogen bond structures and orientation dependence of shock sensitivity in crystalline 1,3,5-tri-amino-2,4,6-tri-nitrobenzene (TATB)
Feng Guo, Kuiguang Yao, Zhipeng Lu, Yu Ma, Yushi Wen, Xiaogan Dai, Ming Li, Xinping Long
2020-04-07
Paper
DOI: 10.1039/C9CP06208D
Tunable relativistic quasiparticle electronic and excitonic behavior of the FAPb(I1−xBrx)3 alloy
Peitao Liu, Saeid Jalali Asadabadi, Cesare Franchini
2020-05-01
Paper
DOI: 10.1039/D0CP00496K
Mixed uranyl and neptunyl cation–cation interaction-driven clusters: structures, energetic stability, and nuclear quadrupole interactions
Paweł Tecmer, Frank Schindler, Aleksandra Leszczyk, Katharina Boguslawski
2020-05-02
Paper
DOI: 10.1039/D0CP01068E
Computational insight into the halogen bonded self-assembly of hexa-coordinated metalloporphyrins
Jyoti Rani, Vratta Grover, Swati Dhamija, Hatem M. Titi
2020-04-20
Paper
DOI: 10.1039/D0CP00351D
The eternal battle to combat global warming: (thio)urea as a CO2 wet scrubbing agent
Ala’a F. Eftaiha, Abdussalam K. Qaroush, Ahed W. Alsayyed, Feda’a Al-Qaisi, Fatima Alsoubani, Khaleel I. Assaf
2020-04-24
Paper
DOI: 10.1039/D0CP00629G
Correlation effects in parallel tempering and the role of the swapping frequency
2020-04-15
Paper
DOI: 10.1039/C9CP06772H
You might also like
Compound Q&A
What are the main uses of 4-Nitrophenyl phosphate disodium salt hexahydrate (CAS: 333338-18-4)?
4-Nitrophenyl phosphate disodium salt hexahydrate is primarily used as a substra...
333338-18-44-Nitrophenyl phosph...
Compound Q&A
What are the main uses of 2-(Trifluoromethyl)-1,3-oxazole-4-carboxylic Acid (CAS: 1060816-01-4)?
2-(Trifluoromethyl)-1,3-oxazole-4-carboxylic Acid (CAS: 1060816-01-4) is widely ...
1060816-01-42-(Trifluoromethyl)-...
Compound Q&A
How should 2-Fluoro-4-biphenylcarboxylic acid (CAS: 137045-30-8) be stored?
2-Fluoro-4-biphenylcarboxylic acid should be stored in a cool, dry place at room...
137045-30-82-Fluoro-4-biphenylc...
Compound Q&A
What industries use Prednisolone-21-Carboxylic Acid (CAS: 61549-70-0)?
Prednisolone-21-Carboxylic Acid is primarily used in the pharmaceutical industry...
61549-70-0Prednisolone-21-Carb...
Compound Q&A
How should 4-(Hydrazinomethyl)-1,2,3-benzenetriol (CAS: 3614-72-0) be stored?
4-(Hydrazinomethyl)-1,2,3-benzenetriol (CAS: 3614-72-0) should be stored in a co...
3614-72-04-(Hydrazinomethyl)-...
Compound Q&A
What industries use 4-Amino-1-methyl-1H-pyrazole-5-carboxylic acid hydrochloride (CAS: 92534-70-8)?
4-Amino-1-methyl-1H-pyrazole-5-carboxylic acid hydrochloride (CAS: 92534-70-8) i...
92534-70-84-Amino-1-methyl-1H-...
Compound Q&A
What regulatory guidelines apply to dehydropachymic acid (CAS: 77012-31-8)?
Dehydropachymic acid (CAS: 77012-31-8) is regulated by various agencies. It fall...
77012-31-8Dehydropachymic acid
Compound Q&A
What is the market or research trend for 6-[(2,2-Dimethylpropanoyl)amino]nicotinic acid (CAS: 898561-66-5)?
The market and research trends for 6-[(2,2-Dimethylpropanoyl)amino]nicotinic aci...
898561-66-56-[(2,2-Dimethylprop...
Compound Q&A
How should 1,10-Phenanthroline-2,9-dicarbaldehyde (CAS: 57709-62-3) be stored?
1,10-Phenanthroline-2,9-dicarbaldehyde should be stored in a cool, dry place awa...
57709-62-31,10-Phenanthroline-...
Compound Q&A
How is 5-Carbamoyl-11-oxo-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate (CAS: 113952-21-9) typically synthesized?
5-Carbamoyl-11-oxo-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate can be synt...
113952-21-95-Carbamoyl-11-oxo-1...
Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![(3R,5R)-1-[(Benzyloxy)carbonyl]-5-methyl-3-piperidinecarboxylic acid structure](https://static.chemtradehub.com/structs/126/1269757-29-0-c552.webp "(3R,5R)-1-[(Benzyloxy)carbonyl]-5-methyl-3-piperidinecarboxylic acid structure")
(3R,5R)-1-[(Benzyloxy)carbonyl]-5-methyl-3-piperidinecarboxylic acid
CAS Number:
1269757-29-0
Molecular Formula:
C15H19NO4
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.