Synthesis of N-indolated amino acids or peptides from 2-alkynylanilines via a dearomatization process
Literature Information
Publication Date
2021-10-07
DOI
10.1039/D1QO01257F
Impact Factor
5.281
Authors
Weilian Qiu, Weiyi Wang, Yin Liu, Renhua Fan
View Original
Abstract
A one-pot stepwise procedure for the synthesis of N-indolated amino acids or peptides from readily available 2-alkynylanilines was reported. The protocol involves the oxidative dearomatization of 2-alkynylanilines, the imino exchange with aliphatic amines, and subsequent cascade cyclization/nucleophilic addition/aromatization. The synthetic method might allow a rapid access to indolactam alkaloid derivatives.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate structure](https://static.chemtradehub.com/structs/137/1373423-53-0-496a.webp "Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate structure")
Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate
CAS Number:
1373423-53-0
Molecular Formula:
C24H27N5O2
4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)morpholine
CAS Number:
485799-04-0
Molecular Formula:
C15H23BN2O3
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