Synthesis of functionalized diarylbenzofurans via Ru-catalyzed C–H activation and cyclization under air: rapid access to the polycyclic scaffold of diptoindonesin G
Literature Information
Lufeng Ouyang, Zhigeng Lin, Shiqi Li, Baoyin Chen, Jidan Liu, Wen-Jing Shi, Liyao Zheng
An efficient method was developed for synthesis of 2,3-diarylbenzofuran-4-carboxylic acids from m-hydroxybenzoic acids and alkynes via Ru-catalyzed C–H alkenylation and aerobic annulation, in which air was employed as a mild oxidant. This method is compatible for various substrates with high regioselectivity for the C–H bonds. The obtained products can be transformed to polycyclic compounds via intramolecular Friedel–Crafts acylation. This protocol was successfully applied for total synthesis of diptoindonesin G, a natural product with a benzofuran-containing tetracyclic scaffold and potent biological activities.
Related Literature
Pristine coconut husk biowaste and 2-ethylhexyl acrylate/methyl acrylate-based novel oleophilic gels for oil spill cleanup
Kavita Devi, Ghanshyam S. Chauhan, Sunita Ranote, Sandeep Chauhan, Kiran Kumar
DOI: 10.1039/D3LP00118K
New sources of genipin-rich substances for crosslinking future manufactured bio-based materials
Maryam Nejati, Yuan Fang, Boyang Guo, Amparo Jiménez-Quero, Antonio J. Capezza, Marcos A. Sabino
DOI: 10.1039/D3SU00303E
Extraction of cellulose from restaurant food waste
Matthew T. Garnett, Harrish Kumar Senthil Kumar, Bryan S. Beckingham, Symone L. M. Alexander
DOI: 10.1039/D3SU00192J
Engineering Pt nanoclusters on CeO2 surface with abundant point defects by in situ confined-domain encapsulation strategy for the catalytic elimination of VOCs
Weiliang Han, Weigao Han, Zhicheng Tang
DOI: 10.1039/D3LF00147D
Exploring metal oxides for the hydrogen evolution reaction (HER) in the field of nanotechnology
Mir Sayed Shah Danish
DOI: 10.1039/D3SU00179B
Recovery of anthocyanins from Eugenia spp. fruit peels: a comparison between heat- and ultrasound-assisted extraction
M. Beatriz P. P. Oliveira
DOI: 10.1039/D3FB00115F
Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties
Filipa Macedo, Telma Guiu, Chris H. J. Franco, Vânia André, Alexander M. Kirillov
DOI: 10.1039/D3LF00123G
A novel shape-stabilized phase change material with tunable thermal conductivity for cold chain applications
Apoorv Balwani, Tridib Ambardar, Adarsh Kumar Pandey, Aravind Dasari, Sujay Chattopadhyay
DOI: 10.1039/D3SU00289F
Effects of different microwave power on the drying kinetics and physicochemical quality of brown shrimp (Metapenaeus dobsoni)
Sumit Kumar Verma, Remya Sasikala, Pankaj Kishore, C. O. Mohan, P. Ganesan, Pandurengan Padmavathy, Nagarajan Muralidharan, Bindu Jaganath, Soottawat Benjakul
DOI: 10.1039/D3FB00144J
You might also like
What industries use (1R,3S)-1,3-Cyclopentanediol (CAS: 16326-97-9)?
(1R,3S)-1,3-Cyclopentanediol finds applications in various industries. In the ph...
What precautions should be taken when handling N'-[4-(Dimethylamino)phenyl]-N,N-dimethyl-1,4-benzenediamine (CAS: 637-31-0)?
When handling N'-[4-(Dimethylamino)phenyl]-N,N-dimethyl-1,4-benzenediamine, it i...
Are there alternatives to 5-(2,4-Difluorophenyl)-2-methoxypyrimidine (CAS: 1352318-16-1) in synthesis?
There are several alternatives to 5-(2,4-Difluorophenyl)-2-methoxypyrimidine in ...
What regulatory guidelines apply to 1-(3-Methoxyphenoxy)propan-2-ol (CAS: 382141-68-6)?
1-(3-Methoxyphenoxy)propan-2-ol (CAS: 382141-68-6) must comply with the Globally...
Is Tetrodotoxin Citrate (CAS: 18660-81-6) safe?
Tetrodotoxin Citrate is extremely dangerous and should be handled with extreme c...
What are the main uses of 2-Methyl-2-propanyl [(1R,3S)-3-hydroxycyclopentyl]carbamate (CAS: 225641-84-9)?
2-Methyl-2-propanyl [(1R,3S)-3-hydroxycyclopentyl]carbamate (CAS: 225641-84-9) i...
How should waste containing 4-(2-Hydroxyhexafluoroisopropyl)Benzoic Acid (CAS: 16261-80-6) be handled?
Waste containing 4-(2-Hydroxyhexafluoroisopropyl)Benzoic Acid (CAS: 16261-80-6) ...
How is 2-Methyl-2-proanyl {(2S)-1-[(benzyloxy)amino]-3-hydroxy-3-methyl-1-oxo-2-butanyl}carbamate (CAS: 102507-19-7) typically synthesized?
2-Methyl-2-proanyl {(2S)-1-[(benzyloxy)amino]-3-hydroxy-3-methyl-1-oxo-2-butanyl...
What is Benzeneethanamine, α-ethyl-, hydrochloride (1:1) (CAS: 20735-15-3)?
Benzeneethanamine, α-ethyl-, hydrochloride (1:1) is an organic compound with the...
Are there alternatives to 3-{(E)-[4-(Dimethylamino)phenyl]diazenyl}benzoic acid (CAS: 20691-84-3) in synthesis?
In the synthesis of compounds similar to 3-{(E)-[4-(Dimethylamino)phenyl]diazeny...
Source Journal
Organic Chemistry Frontiers

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry













![N-[(5,6-Dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine structure N-[(5,6-Dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine structure](https://static.chemtradehub.com/structs/238/2387704-62-1-25f4.webp)
![Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate structure Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate structure](https://static.chemtradehub.com/structs/137/1373423-53-0-496a.webp)