3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine
CAS Number:
1032758-99-8
Molecular Formula:
C11H16BClN2O2
Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay
Literature Information
Publication Date
2021-08-24
DOI
10.1039/D1MD00215E
Impact Factor
0
Authors
Guilherme Vieira de Castro, Alessio Ciulli
View Original
Abstract
Cooperativity is an important parameter to understand the ternary complexes formed by protein degraders. We developed fluorine NMR competition binding experiments to determine cooperativity of PROTACs. We show applicability to estimate both positive and negative cooperativity, also with homo-dimerizers, and highlight key features and considerations for optimal assay development.
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909187-64-0
Molecular Formula:
C13H15N3O
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