Methyl 2-amino-4-(4-chlorophenyl)-5-pyrimidinecarboxylate
CAS Number:
1133115-56-6
Molecular Formula:
C12H10ClN3O2
A lysosome-targeted probe for the real-time detection of hypobromous acid in living human cancer cells
Literature Information
Publication Date
2021-02-23
DOI
10.1039/D1AN00147G
Impact Factor
4.616
Authors
Yali Wang, Yuan Zhang, Lijun Yang, Huiyuan Wu, Nathaniel Finney
View Original
Abstract
We reported here a naphthalimide-based fluorescent probe LysOBr that localizes in the lysosome in live cells. LysOBr exhibits excellent HOBr selectivity and desirable optical properties. It can quantitatively detect lysosomal HOBr at 0–20 μM, with a detection limit of 243 nM. The short (4 s) response time allows real-time HOBr detection and imaging, as shown with studies in live HeLa cancer cells. It is thus the most rapidly responsive HOBr probe to date, among the most selective ones, and the first probe that is lysosome-specific with a “turn-on” signal. The probe structure is modular, and convenient structural modification should lead to other organelle-specific probes.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
![1-Benzyl-1,7-diazaspiro[4.4]nonane dihydrochloride structure](https://static.chemtradehub.com/structs/115/1159822-71-5-0320.webp "1-Benzyl-1,7-diazaspiro[4.4]nonane dihydrochloride structure")
1-Benzyl-1,7-diazaspiro[4.4]nonane dihydrochloride
CAS Number:
1159822-71-5
Molecular Formula:
C14H22Cl2N2
BIS(I-PROPYLCYCLOPENTADIENYL)TITANIUM DICHLORIDE
CAS Number:
12130-65-3
Molecular Formula:
C16H22Cl2Ti
(S)-1-(3-(Benzyloxy)phenyl)-3-(dimethylamino)-2-methylpropan-1-one (2r,3r)-2,3-bis(benzoyloxy)succinate
CAS Number:
1004315-81-4
Molecular Formula:
C37H37NO10
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