A continuous-flow approach for the multi-gram scale synthesis of C2-alkyl- or β-amino functionalized 1,3-dicarbonyl derivatives and ondansetron drug using 1,3-dicarbonyls
Literature Information
Nirmala Mohanta, Krishna Nair, Dasharath Vishambar Sutar, Boopathy Gnanaprakasam
Continuous-flow chemistry is a modern technology that encompasses the green chemistry principles for the multi-gram synthesis of various API and drugs. Herein, we have developed a highly efficient and environmentally benign metal-free alkylation of 1,3-dicarbonyl compounds using secondary alcohols in the presence of inexpensive Amberlyst®-15 under continuous-flow. This method has a broad substrate scope with a variety of secondary alcohols and water as a byproduct. The Amberlyst®-15 is recyclable and reusable for the alkylation reaction under batch/continuous-flow technology. Furthermore, a continuous-flow technology driven Mannich reaction was demonstrated under an acid-free condition. In addition, a continuous-flow Fischer indole strategy for the ondansetron with an improved yield was demonstrated. Additionally, all these reactions were demonstrated with multi-gram scale synthesis without lowering the yield under batch/continuous-flow technology.
Recommended Journals
Related Literature
Electrophilicity parameters for σ-complexation by uncharged electron-deficient aromatic and heteroaromatic structures
François Terrier, Régis Goumont, Taoufik Boubaker, Erwin Buncel
DOI: 10.1039/B410356D
New Pb–Pb bonds: syntheses and molecular structures of hexabiphenyldiplumbane and tri(trisbiphenylplumbyl)plumbate
Yuzhong Wang, Brandon Quillian, Pingrong Wei, Xiao-Juan Yang, Gregory H. Robinson
DOI: 10.1039/B408860N
A new organic superconductor β-(meso-DMBEDT-TTF)2PF6
Tadashi Kawamoto, Takehiko Mori, Hiroshi Moriyama, Yutaka Nishio, Koji Kajita
DOI: 10.1039/B409631B
A very large Rh–Rh bond shortening on excitation of the [Rh2(1,8-diisocyano-p-menthane)4]2+ ion by time-resolved synchrotron X-ray diffraction
Yu-Sheng Chen, Tim Graber
DOI: 10.1039/B409463H
A mixed ladderane/n-alkyl glycerol diether membrane lipid in an anaerobic ammonium-oxidizing bacterium
Jaap S. Sinninghe Damsté, W. Irene C. Rijpstra, Marc Strous, Mike S. M. Jetten, Olivier R. P. David, Jan A. J. Geenevasen, Jan H. van Maarseveen
DOI: 10.1039/B409806D
A samarium cyclooctatetraene complex as catalyst for hydroamination/cyclisation catalysis
Agustino Zulys, Tarun K. Panda, Michael T. Gamer, Peter W. Roesky
DOI: 10.1039/B410918J
Novel Pt/CeO2/C catalysts for electrooxidation of alcohols in alkaline media
Changwei Xu, Pei Kang Shen
DOI: 10.1039/B408589B
A regioregular polyalkylthiophene bearing covalently-linked biotin, and its interaction with avidin in solution and in thin films
Fouzi Mouffouk, Simon J. Higgins, Stewart J. Brown, Naser Sedghi, Bill Eccleston, Stuart Reeman
DOI: 10.1039/B408935A
An active ferrocenyl triarylphosphine for palladium-catalyzed Suzuki–Miyaura cross-coupling of aryl halides
Fuk Yee Kwong, Kin Shing Chan, Chi Hung Yeung, Albert S. C. Chan
DOI: 10.1039/B407661C
Synthesis and characterization of electron-rich nickel tris-carbene complexes‡
Xile Hu, Ingrid Castro-Rodriguez, Karsten Meyer
DOI: 10.1039/B409241D
You might also like
What is 1-(2,4,6-Trifluorophenyl)ethanol (CAS: 1250113-83-7)?
1-(2,4,6-Trifluorophenyl)ethanol is an organic compound with the CAS number 1250...
Is 1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) safe?
1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) is ...
What are the physical and chemical properties of (7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one (CAS: 51419-51-3)?
(7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one is a crystal...
What regulatory guidelines apply to rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3618-04-0)?
The compound rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3...
What is the market or research trend for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3)?
The market for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3) is cur...
What are the main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9)?
The main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9) include research in ...
What precautions should be taken when handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5)?
When handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5), i...
How is 5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) typically synthesized?
5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) can be synthesi...
Are there alternatives to 2,4,6-Trihydroxyisophthalaldehyde (CAS: 4396-13-8) in synthesis?
There are alternative reagents that can be used in the synthesis of 2,4,6-Trihyd...
What is (2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid (CAS: 179461-52-0)?
(2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid is a chemical compound wi...
Source Journal
Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.














