Synthesis of spiro(indoline-2,3′-hydropyridazine) via an “on-water” [4 + 2] annulation reaction
Literature Information
Publication Date
2020-12-22
DOI
10.1039/D0QO01422B
Impact Factor
5.281
Authors
Wei-Fang Zuo, Jin Zhou, Yu-Ling Wu, Hua-Ying Fang, Xing-Jiang Lang, Ya Li, Gu Zhan, Bo Han
View Original
Abstract
An on-water [4 + 2] annulation reaction between the 2-methyl-3H-indolium salt and α-bromo N-acyl hydrazone has been developed. The environmentally friendly strategy provides the first facile access to spiro(indoline-2,3′-hydropyridazine) scaffolds. Compared with the reaction in organic solvents, the use of water as the sole solvent remarkably improves the reaction efficiency as well as chemoselectivity. This green protocol features high yield, broad substrate scope, and mild reaction conditions.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![Bis[(1,2,3,4,5-eta)-1-(diphenylphosphino)cyclopentadienyl]iron structure](https://static.chemtradehub.com/structs/121/12150-46-8-ecd2.webp "Bis[(1,2,3,4,5-eta)-1-(diphenylphosphino)cyclopentadienyl]iron structure")
Bis[(1,2,3,4,5-eta)-1-(diphenylphosphino)cyclopentadienyl]iron
CAS Number:
12150-46-8
Molecular Formula:
C34H28FeP2
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