Photo-induced preparation of unnatural α-amino acids: synthesis and characterization of novel Leu5-enkephalin analogues
Literature Information
Publication Date
2020-07-28
DOI
10.1039/D0QO00696C
Impact Factor
5.281
Authors
Hongxiang Xue, Mengzhun Guo, Chao Wang, Yuxuan Shen, Rupeng Qi, Yifei Wu, Zhaoqing Xu, Min Chang
View Original
Abstract
We here report the first example of the photo-induced preparation of unnatural α-amino acids and modification of peptides with unactivated alkyl chlorides (iodides) without the assistance of a transition metal catalyst or photosensitizer. The method was successfully applied for the late-stage modification of peptides and provided a novel enkephalin analogue with significantly better analgesic activity and 2.6-fold more long-lasting time compared to its parent peptide.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![3,7-Di(1,1':3',1''-terphenyl-5'-yl)-10,11,12,13-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-ol 5-oxide structure](https://static.chemtradehub.com/structs/135/1352810-38-8-3f10.webp "3,7-Di(1,1':3',1''-terphenyl-5'-yl)-10,11,12,13-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-ol 5-oxide structure")
3,7-Di(1,1':3',1''-terphenyl-5'-yl)-10,11,12,13-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-ol 5-oxide
CAS Number:
1352810-38-8
Molecular Formula:
C53H39O4P
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