Rh-Catalyzed nitrene alkyne metathesis/formal C–N bond insertion cascade: synthesis of 3-iminoindolines
Literature Information
Publication Date
2020-04-08
DOI
10.1039/D0QO00294A
Impact Factor
5.281
Authors
Kemiao Hong, Su Zhou, Wenhao Hu
View Original
Abstract
A Rh2(esp)2 catalyzed nitrene/alkyne metathesis (NAM) cascade reaction of alkyne-tethered sulfamates has been developed, which provides facile access to the tricyclic 3-iminoindolines in good to excellent yields with broad substrate scope. The reaction is initiated by a Rh-promoted nitrene/alkyne metathesis (NAM) under oxidative conditions to form the key α-imino metal carbene intermediate, followed by a formal carbene insertion reaction of the amide C–N bond via a Stevens [1,2]-acyl shift.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate
CAS Number:
1373423-53-0
Molecular Formula:
C24H27N5O2
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N-[(5,6-Dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine
CAS Number:
2387704-62-1
Molecular Formula:
C21H20Cl2N10O
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