![Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate structure](https://static.chemtradehub.com/structs/137/1373423-53-0-496a.webp "Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate structure")
Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate
CAS Number:
1373423-53-0
Molecular Formula:
C24H27N5O2
Synthesis of polysubstituted 5-trifluoromethyl isoxazoles via denitrogenative cyclization of vinyl azides with trifluoroacetic anhydride
Literature Information
Publication Date
2020-06-08
DOI
10.1039/D0QO00243G
Impact Factor
5.281
Authors
Wei Wu, Qiaoling Chen, Yishi Tian, Yihui Xu, Yangjie Huang, Yi You, Zhiqiang Weng
View Original
Abstract
We describe a general method for the synthesis of 5-(trifluoromethyl)isoxazoles by denitrogenative cyclization of vinyl azides with trifluoroacetic anhydride in the presence of NEt3. The scope of this protocol was further extended to the synthesis of perfluoroalkylated isoxazoles. This reaction allows facile synthesis of structurally diverse 5-(perfluoroalkyl)isoxazole derivatives with various vinyl azides.
Related Literature
Construction of Pd–TiOx interfaces for selective hydrodeoxygenation of CO bonds in vanillin by supporting Pd nanoparticles on ETS-10 zeolite
Jianbin Huang, Chang Zhou, Jian Zhang, Hao Meng, Shiyao Lu
2023-11-14
Paper
DOI: 10.1039/D3SU00271C
Alkali and alkaline earth metals in liquid salts for supercapatteries
Peiying Fan, Yuhan Zhang, Li Guan, Han Wang, George Zheng Chen
2023-11-29
Tutorial Review
DOI: 10.1039/D3SU00197K
Assessing weight loss control strategies in pomegranate (Punica granatum L.) fruit: plastic packaging and surface waxing
Alemayehu Ambaw
2023-09-30
Paper
DOI: 10.1039/D3FB00089C
Simultaneous production of proteases and antioxidant biopeptides by solid-state fermentation
Luciane Maria Colla, Christian Oliveira Reinehr, Paola Gouvêa Manfredini, Vítor Augusto Farina Cavanhi, Jorge Alberto Vieira Costa
2023-08-29
Paper
DOI: 10.1039/D3FB00077J
Nanoporous oxide electrodes for energy conversion and storage devices
Jin Wook Yang, Hee Ryeong Kwon, Jin Ho Seo, Sangwoo Ryu
2023-10-09
Review Article
DOI: 10.1039/D3LF00094J
Development of strong and high-barrier food packaging films from cyclic-anhydride modified bacterial cellulose
Zhuolun Jiang, Ka Man Cheung, To Ngai
2023-10-23
Paper
DOI: 10.1039/D3SU00219E
A green process for the specific decomposition of chicken feather keratin into polythiol building blocks
Julia Diener, Christian Bartsch, Florian Dietrich, Claudia Falcke, Iva Anic, Steffen Roth, Andreas Taden, Michael Richter
2023-12-07
Paper
DOI: 10.1039/D3SU00269A
The role of ceria/precious metal interfaces in catalysis
Michele Melchionna
2023-11-29
Perspective
DOI: 10.1039/D3LF00202K
Engineering Pt nanoclusters on CeO2 surface with abundant point defects by in situ confined-domain encapsulation strategy for the catalytic elimination of VOCs
Weiliang Han, Weigao Han, Zhicheng Tang
2023-10-09
Paper
DOI: 10.1039/D3LF00147D
You might also like
Compound Q&A
What industries use (1R,3S)-1,3-Cyclopentanediol (CAS: 16326-97-9)?
(1R,3S)-1,3-Cyclopentanediol finds applications in various industries. In the ph...
16326-97-9(1R,3S)-1,3-Cyclopen...
Compound Q&A
What precautions should be taken when handling N'-[4-(Dimethylamino)phenyl]-N,N-dimethyl-1,4-benzenediamine (CAS: 637-31-0)?
When handling N'-[4-(Dimethylamino)phenyl]-N,N-dimethyl-1,4-benzenediamine, it i...
637-31-0N'-[4-(Dimethylamino...
Compound Q&A
Are there alternatives to 5-(2,4-Difluorophenyl)-2-methoxypyrimidine (CAS: 1352318-16-1) in synthesis?
There are several alternatives to 5-(2,4-Difluorophenyl)-2-methoxypyrimidine in ...
1352318-16-15-(2,4-Difluoropheny...
Compound Q&A
What regulatory guidelines apply to 1-(3-Methoxyphenoxy)propan-2-ol (CAS: 382141-68-6)?
1-(3-Methoxyphenoxy)propan-2-ol (CAS: 382141-68-6) must comply with the Globally...
382141-68-61-(3-Methoxyphenoxy)...
Compound Q&A
Is Tetrodotoxin Citrate (CAS: 18660-81-6) safe?
Tetrodotoxin Citrate is extremely dangerous and should be handled with extreme c...
18660-81-6Tetrodotoxin Citrate
Compound Q&A
What are the main uses of 2-Methyl-2-propanyl [(1R,3S)-3-hydroxycyclopentyl]carbamate (CAS: 225641-84-9)?
2-Methyl-2-propanyl [(1R,3S)-3-hydroxycyclopentyl]carbamate (CAS: 225641-84-9) i...
225641-84-92-Methyl-2-propanyl ...
Compound Q&A
How should waste containing 4-(2-Hydroxyhexafluoroisopropyl)Benzoic Acid (CAS: 16261-80-6) be handled?
Waste containing 4-(2-Hydroxyhexafluoroisopropyl)Benzoic Acid (CAS: 16261-80-6) ...
16261-80-64-(2-Hydroxyhexafluo...
Compound Q&A
How is 2-Methyl-2-proanyl {(2S)-1-[(benzyloxy)amino]-3-hydroxy-3-methyl-1-oxo-2-butanyl}carbamate (CAS: 102507-19-7) typically synthesized?
2-Methyl-2-proanyl {(2S)-1-[(benzyloxy)amino]-3-hydroxy-3-methyl-1-oxo-2-butanyl...
102507-19-72-Methyl-2-propanyl ...
Compound Q&A
What is Benzeneethanamine, α-ethyl-, hydrochloride (1:1) (CAS: 20735-15-3)?
Benzeneethanamine, α-ethyl-, hydrochloride (1:1) is an organic compound with the...
20735-15-3Benzeneethanamine, α...
Compound Q&A
Are there alternatives to 3-{(E)-[4-(Dimethylamino)phenyl]diazenyl}benzoic acid (CAS: 20691-84-3) in synthesis?
In the synthesis of compounds similar to 3-{(E)-[4-(Dimethylamino)phenyl]diazeny...
20691-84-33-{(E)-[4-(Dimethyla...
Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
5,7,8'-Trihydroxy-2',2'-dimethyl-2'H,4H-3,6'-bichromen-4-one
CAS Number:
129280-33-7
Molecular Formula:
C20H16O6
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.