Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeability
Literature Information
Publication Date
2021-01-12
DOI
10.1039/D0MD00408A
Impact Factor
0
Authors
Chiara Borsari, Erhan Keles, Andrea Treyer, Martina De Pascale, Matthias Hamburger, Matthias P. Wymann
View Original
Abstract
Highly selective mTOR inhibitors have been discovered through the exploration of the heteroaromatic ring engaging the binding affinity region in mTOR kinase. Compound 11 showed predicted BBB permeability in a MDCK-MDR1 permeability in vitro assay, being the first pyrimido-pyrrolo-oxazine with potential application in the treatment of neurological disorders.
Related Literature
A one-step colorimetric acid–base titration sensor using a complementary color changing coordination system
Hui Hun Cho, Si Hyun Kim, Jun Hyuk Heo, Young Eel Moon, Young Hun Choi, Dong Cheol Lim, Kwon-Hoon Han
2016-04-21
Paper
DOI: 10.1039/C6AN00744A
Soft-trilinear constraints for improved quantitation in multivariate curve resolution
Hamid Abdollahi, Paul J. Gemperline
2019-11-11
Paper
DOI: 10.1039/C8AN00615F
Styrylpyridine salts-based red emissive two-photon turn-on probe for imaging the plasma membrane in living cells and tissues
Lifang Guo, Ruoyao Zhang, Yuming Sun, Minggang Tian, Ge Zhang, Ruiqing Feng, Xuechen Li, Xiaoqiang Yu, Xiuquan He
2016-04-26
Communication
DOI: 10.1039/C6AN00147E
Attenuated total reflection Fourier-transform infrared spectral discrimination in human bodily fluids of oesophageal transformation to adenocarcinoma
Ishaan Maitra, Camilo L. M. Morais, Katherine M. Ashton, Ravindra S. Date, Francis L. Martin
2019-10-31
Paper
DOI: 10.1039/C9AN01749F
An in vivo quantitative Raman-pH sensor of arterial blood based on laser trapping of erythrocytes
Manman Lin, Bin Xu, Huilu Yao, Aiguo Shen, Jiming Hu
2016-03-23
Paper
DOI: 10.1039/C5AN02315G
An ionic liquid composed of purely functional sensing molecules: a colorimetrically calcium responsive ionic liquid
Yusuke Niwa, Tatsumi Mizuta, Kenji Sueyoshi, Tatsuro Endo, Hideaki Hisamoto
2019-10-21
Communication
DOI: 10.1039/C9AN01769K
Cooperative hydrogen-bonding of the adenine–thymine pair as a strategy for lowering the limit of detection of thymine by surface-enhanced Raman spectroscopy
Mónica B. Mamián-López, Paola Corio, Marcia L. A. Temperini
2016-04-20
Paper
DOI: 10.1039/C6AN00222F
Enzyme-linked immunosorbent assay utilizing thin-layered microfluidics
Tatsuro Nakao, Yutaka Kazoe, Emi Mori, Hisashi Shimizu
2019-09-18
Paper
DOI: 10.1039/C9AN01491H
Enzymatic reaction-based nanopore detection of zinc ions
Golbarg Mohammadi Roozbahani, Youwen Zhang, Xiaohan Chen, Mona Hoseini Soflaee, Xiyun Guan
2019-10-18
Paper
DOI: 10.1039/C9AN01784D
Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis
Jonathan Sjögren, Fredrik Olsson, Alain Beck
2016-05-04
Minireview
DOI: 10.1039/C6AN00071A
You might also like
Compound Q&A
How should waste containing 6-Chloro-5-(2'-hydroxy-3'-methoxy-4-biphenylyl)-3-(3-methoxyphenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione (CAS: 1346607-05-3) be handled?
Waste containing 6-Chloro-5-(2'-hydroxy-3'-methoxy-4-biphenylyl)-3-(3-methoxyphe...
1346607-05-36-Chloro-5-(2'-hydro...
Compound Q&A
What are the main uses of (3alpha,5alpha)-3-Hydroxypregnane-11,20-dione (CAS: 23930-19-0)?
(3alpha,5alpha)-3-Hydroxypregnane-11,20-dione is primarily used in the pharmaceu...
23930-19-0(3alpha,5alpha)-3-Hy...
Compound Q&A
What is the market or research trend for 4-Amino-6-chloro-2-pyridinecarboxylic acid (CAS: 546141-56-4)?
The market for 4-Amino-6-chloro-2-pyridinecarboxylic acid (CAS: 546141-56-4) is ...
546141-56-44-Amino-6-chloro-2-p...
Compound Q&A
Are there alternatives to (2-Benzoylethyl)trimethylammonium chloride (CAS: 24472-88-6) in synthesis?
Alternatives to (2-Benzoylethyl)trimethylammonium chloride (CAS: 24472-88-6) in ...
24472-88-6(2-Benzoylethyl)trim...
Compound Q&A
Is N-[4-Nitro-3-(trifluoromethyl)phenyl]acetamide (CAS: 393-12-4) safe?
N-[4-Nitro-3-(trifluoromethyl)phenyl]acetamide (CAS: 393-12-4) is generally safe...
393-12-4N-[4-Nitro-3-(triflu...
Compound Q&A
Are there alternatives to [(4R,5R,6S)-5-hydroxy-10-imino-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-4-yl]methyl dihydrogen phosphate (CAS: 39679-56-6) in synthesis?
Alternative reagents such as other phosphates or similar functional groups can b...
39679-56-6[(4R,5R,6S)-5-hydrox...
Compound Q&A
Are there alternatives to N,N'-Bis(3-aminopropyl)-1,3-propanediamine (CAS: 4605-14-5) in synthesis?
There are alternatives to N,N'-Bis(3-aminopropyl)-1,3-propanediamine (CAS: 4605-...
4605-14-5N,N'-Bis(3-aminoprop...
Compound Q&A
What precautions should be taken when handling Aluminium trihexadecanoate (CAS: 555-35-1)?
When handling Aluminium trihexadecanoate, it is important to use appropriate per...
555-35-1Aluminium trihexadec...
Compound Q&A
What is (1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetic acid (CAS: 52188-11-1)?
(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetic acid is a chemical compound ...
52188-11-1(1,1-Dioxido-3-oxo-1...
Compound Q&A
Are there alternatives to 5,5-dimethyloxolan-2-one (CAS: 3123-97-5) in synthesis?
Several alternatives to 5,5-dimethyloxolan-2-one (CAS: 3123-97-5) can be used in...
3123-97-55,5-dimethyloxolan-2...
Source Journal
Recommended Compounds
6-Butyl-2-(2,4-difluorophenyl)-1,3,6,2-dioxazaborocane
CAS Number:
1190988-98-7
Molecular Formula:
C14H20BF2NO2
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.