![2-morpholino-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethanamine structure](https://static.chemtradehub.com/structs/119/1192570-20-9-2810.webp "2-morpholino-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethanamine structure")
2-morpholino-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethanamine
CAS Number:
1192570-20-9
Molecular Formula:
C11H15F3N4O
Put a ring on it: application of small aliphatic rings in medicinal chemistry
Literature Information
Publication Date
2021-01-07
DOI
10.1039/D0MD00370K
Impact Factor
0
Authors
Matthias R. Bauer, Paolo Di Fruscia, Simon C. C. Lucas, Iacovos N. Michaelides, Jennifer E. Nelson, R. Ian Storer, Benjamin C. Whitehurst
View Original
Abstract
Aliphatic three- and four-membered rings including cyclopropanes, cyclobutanes, oxetanes, azetidines and bicyclo[1.1.1]pentanes have been increasingly exploited in medicinal chemistry for their beneficial physicochemical properties and applications as functional group bioisosteres. This review provides a historical perspective and comparative up to date overview of commonly applied small rings, exemplifying key principles with recent literature examples. In addition to describing the merits and advantages of each ring system, potential hazards and liabilities are also illustrated and explained, including any significant chemical or metabolic stability and toxicity risks.
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Source Journal
Recommended Compounds
5-(2-Methyl-1,3-thiazol-4-yl)-2-thiophenesulfonyl chloride
CAS Number:
215434-25-6
Molecular Formula:
C8H6ClNO2S3
![4-{[4-(Trifluoromethoxy)benzyl]oxy}benzonitrile structure](https://static.chemtradehub.com/structs/103/1036629-63-6-2172.webp "4-{[4-(Trifluoromethoxy)benzyl]oxy}benzonitrile structure")
4-{[4-(Trifluoromethoxy)benzyl]oxy}benzonitrile
CAS Number:
1036629-63-6
Molecular Formula:
C15H10F3NO2
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