Aquaporin-driven hydrogen peroxide transport: a case of molecular mimicry?

Literature Information

Publication Date 2020-11-25
DOI 10.1039/D0CB00160K
Impact Factor 0
Authors

Darren Wragg, Stefano Leoni, Angela Casini


View Original

Abstract

Aquaporins (AQPs) are membrane proteins that have evolved to control cellular water uptake and efflux, and as such are amongst the most ancient biological “devices” in cellular organisms. Recently, using metadynamics, we have shown that water nanoconfinement within aquaporin channels results into bidirectional water movement along single file chains, extending previous investigations. Here, the elusive mechanisms of H2O2 facilitated transport by the human ‘peroxiporin’ AQP3 has been unravelled via a combination of atomistic simulations, showing that while hydrogen peroxide is able to mimic water during AQP3 permeation, this comes at a certain energy expense due to the required conformational changes within the channel. Furthermore, the intrinsic water dynamics allows for host H2O2 molecule solvation and transport in both directions, highlighting the fundamental role of water nanoconfinement for successful transduction and molecular selection. Overall, the bidirectional nature of the water flux under equilibrium conditions along with the mimicking behavior of hydrogen peroxide during a conductance event introduce a new chemical paradigm never reported so far in any theoretical paper involving any aquaporin isoform.

Related Literature

Transformation of PbI2, PbBr2 and PbCl2 salts into MAPbBr3 perovskite by halide exchange as an effective method for recombination reduction

Marta Vallés-Pelarda, Bruno Clasen Hames, Rafael S. Sanchez, Eva M. Barea, Hager Maghraoui-Meherzi, Iván Mora-Seró

2017-03-30 Paper

DOI: 10.1039/C7CP01192J

Intracellular-molecular changes in plasma-irradiated budding yeast cells studied using multiplex coherent anti-Stokes Raman scattering microscopy

Ryo Furuta, Naoyuki Kurake, Kenji Ishikawa, Keigo Takeda, Hiroshi Hashizume, Hiroki Kondo, Takayuki Ohta, Masafumi Ito, Makoto Sekine, Masaru Hori

2017-04-27 Communication

DOI: 10.1039/C7CP00489C

Addressing uncertainty in atomistic machine learning

Andrew A. Peterson, Rune Christensen, Alireza Khorshidi

2017-04-18 Perspective

DOI: 10.1039/C7CP00375G

Increased substrate affinity in the Escherichia coli L28R dihydrofolate reductase mutant causes trimethoprim resistance

Haleh Abdizadeh, Yusuf Talha Tamer, Omer Acar, Erdal Toprak, Ali Rana Atilgan, Canan Atilgan

2017-04-03 Paper

DOI: 10.1039/C7CP01458A

Contents list

Front/Back Matter

DOI: 10.1039/C7CP90121F

Mechanical and vibrational characterization of amyloid-like HET-s nanosheets based on the skewed plate theory

Hyun Joon Chang, Myeongsang Lee, Jae In Kim, Sungsoo Na

2017-04-03 Paper

DOI: 10.1039/C7CP01418J

Editorial of the PCCP themed issue on “Physical Chemistry for Life Sciences”

Christoph van Wüllen, Kirsten Schwing, Christoph Riehn, Markus Gerhards

2017-04-19 Editorial

DOI: 10.1039/C7CP90069D

Single-layer MoS2 formation by sulfidation of molybdenum oxides in different oxidation states on Au(111)

Norberto Salazar, Igor Beinik, Jeppe V. Lauritsen

2017-04-20 Paper

DOI: 10.1039/C7CP00958E

Thermal mismatch strain induced disorder of Y2Mo3O12 and its effect on thermal expansion of Y2Mo3O12/Al composites

Chang Zhou, Qiang Zhang, Saiyue Liu, Bingcheng Luo, Eongyu Yi, Enke Tian, Guowu Li, Longtu Li, Gaohui Wu

2017-04-13 Paper

DOI: 10.1039/C7CP00676D

You might also like

Compound Q&A

How should waste containing N-Methoxy-N-methyl-1,3-thiazole-5-carboxamide (CAS: 898825-89-3) be handled?

Waste containing N-Methoxy-N-methyl-1,3-thiazole-5-carboxamide (CAS: 898825-89-3...

898825-89-3N-Methoxy-N-methyl-1...
Compound Q&A

How should N-(4-Biphenylyl)dibenzo[b,d]furan-4-amine (CAS: 1318338-47-4) be stored?

N-(4-Biphenylyl)dibenzo[b,d]furan-4-amine should be stored in a tightly sealed c...

1318338-47-4N-(4-Biphenylyl)dibe...
Compound Q&A

What is the market or research trend for 3-Acetamido-5-amino-2,4,6-triiodobenzoic acid (CAS: 1713-07-1)?

The market for 3-Acetamido-5-amino-2,4,6-triiodobenzoic acid (CAS: 1713-07-1) is...

1713-07-13-Acetamido-5-amino-...
Compound Q&A

How should Benzyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-galactopyranoside (CAS: 61820-03-9) be stored?

Benzyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-galactopyranoside (CAS: 61820-03-9) ...

61820-03-9Benzyl 2-O-acetyl-3,...
Compound Q&A

What regulatory guidelines apply to 2-Ethylpiperazine dihydrochloride (CAS: 438050-52-3)?

2-Ethylpiperazine dihydrochloride (CAS: 438050-52-3) is regulated under the Glob...

438050-52-32-Ethylpiperazine di...
Compound Q&A

What regulatory guidelines apply to 1,1'-[1,3-Phenylenebis(methylene)]bis(3-methyl-1H-pyrrole-2,5-dione) (CAS: 119462-56-5)?

1,1'-[1,3-Phenylenebis(methylene)]bis(3-methyl-1H-pyrrole-2,5-dione) (CAS: 11946...

119462-56-51,1'-[1,3-Phenyleneb...
Compound Q&A

Are there alternatives to 5-Fluoro-2-(1-pyrrolidinyl)pyridine (CAS: 1287217-79-1) in synthesis?

Several alternatives can be used in the synthesis of 5-Fluoro-2-(1-pyrrolidinyl)...

1287217-79-15-Fluoro-2-(1-pyrrol...
Compound Q&A

What precautions should be taken when handling 6-Bromoimidazo[1,2-a]pyridin-8-amine (CAS: 676371-00-9)?

When handling 6-Bromoimidazo[1,2-a]pyridin-8-amine, it is important to wear appr...

676371-00-96-Bromoimidazo[1,2-a...
Compound Q&A

Are there alternatives to (2S,4R)-4-(4-Nitrobenzyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS: 1049740-22-8) in synthesis?

Alternatives to (2S,4R)-4-(4-Nitrobenzyl)pyrrolidine-2-carboxylic acid hydrochlo...

1049740-22-8(2S,4R)-4-(4-Nitrobe...

Source Journal

RSC Chemical Biology

RSC Chemical Biology
CiteScore: 0
Self-citation Rate: 0%
Articles per Year: 0

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.