![4-{2-[4-(2-Methyl-2-propanyl)phenyl]ethoxy}quinazoline structure](https://static.chemtradehub.com/structs/120/120928-09-8-d3db.webp "4-{2-[4-(2-Methyl-2-propanyl)phenyl]ethoxy}quinazoline structure")
4-{2-[4-(2-Methyl-2-propanyl)phenyl]ethoxy}quinazoline
CAS Number:
120928-09-8
Molecular Formula:
C20H22N2O
Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors
Literature Information
Publication Date
2020-09-16
DOI
10.1039/D0CB00111B
Impact Factor
0
Authors
Grace E. Hubbell, Jetze J. Tepe
View Original
Abstract
The 20S proteasome is a valuable target for the treatment of a number of diseases including cancer, neurodegenerative disease, and parasitic infection. In an effort to discover novel inhibitors of the 20S proteasome, many reseaarchers have looked to natural products as potential leads for drug discovery. The following review discusses the efforts made in the field to isolate and identify natural products as inhibitors of the proteasome. In addition, we describe some of the modifications made to natural products in order to discover more potent and selective inhibitors for potential disease treatment.
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