Green and catalyst-free synthesis of deoxyarbutin in continuous-flow
Literature Information
Xiaoxuan Xie, Shitian Xie, Hongmiao Yao, Xin Ye, Zhiqun Yu
A one-step catalyst-free continuous-flow etherification protocol has been developed for the preparation of deoxyarbutin. The starting material hydroquinone was etherified with 3,4-dihydro-2H-pyran (DHP) to gain deoxyarbutin directly. A material recycling method was established to address the drawback of low per pass conversion which is caused by the reversible equilibrium of this reaction. The continuous-flow methodology is effective in inhibiting the double etherification side reaction to realize the facile and highly efficient preparation of deoxyarbutin.
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Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.














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