Green and catalyst-free synthesis of deoxyarbutin in continuous-flow

Literature Information

Publication Date 2019-02-28
DOI 10.1039/C9RE00084D
Impact Factor 4.239
Authors

Xiaoxuan Xie, Shitian Xie, Hongmiao Yao, Xin Ye, Zhiqun Yu


View Original

Abstract

A one-step catalyst-free continuous-flow etherification protocol has been developed for the preparation of deoxyarbutin. The starting material hydroquinone was etherified with 3,4-dihydro-2H-pyran (DHP) to gain deoxyarbutin directly. A material recycling method was established to address the drawback of low per pass conversion which is caused by the reversible equilibrium of this reaction. The continuous-flow methodology is effective in inhibiting the double etherification side reaction to realize the facile and highly efficient preparation of deoxyarbutin.

Related Literature

Cage lifetimes of ionic liquids as studied by the magnetic field effect probe

Tomohide Okada, Tomoaki Yago, Tadashi Takamasu, Masanobu Wakasa

2012-01-17 Paper

DOI: 10.1039/C2CP23747D

Bombardment induced ion transport – Part III: Experimental potassium ion conductivities in poly(para-xylylene)

S. Schulze, M. Schäfer, A. Greiner, K.-M. Weitzel

2012-11-23 Paper

DOI: 10.1039/C2CP43144K

Density functional theory study of the structure and vibrational modes of acrylonitrile adsorbed on Cu(100)

Sergio Díaz-Tendero, Manuel Alcamí

2012-11-08 Paper

DOI: 10.1039/C2CP42542D

Can hydrate form in carbon dioxide from dissolved water?

Bjørn Kvamme, Tatiana Kuznetsova, Pilvi-Helina Kivelæ, Jordan Bauman

2012-11-28 Paper

DOI: 10.1039/C2CP43061D

Possible presence of hydrophilic SO3H nanoclusters on the surface of dry ultrathin Nafion® films: a positron annihilation study

Hamdy F. M. Mohamed, S. Kuroda, Y. Kobayashi, N. Oshima, R. Suzuki

2012-11-22 Paper

DOI: 10.1039/C2CP43727A

Theoretical studies on the transport mechanism of 5-fluorouracil through cyclic peptide based nanotubes

Sofie Van Damme, Patrick Bultinck, Venkatesan Subramanian

2012-10-23 Paper

DOI: 10.1039/C2CP42038D

Understanding the different activities of highly promiscuous MbtI by computational methods

Silvia Ferrer, Sergio Martí, Vicent Moliner, Iñaki Tuñón, Juan Bertrán

2012-01-17 Paper

DOI: 10.1039/C2CP23149B

The nature of phase separation in a Ru–Sn–O ternary oxide electrocatalyst

Xin Wang, Fenyong Deng, Zhongzhi Tang, Bo Wu

2013-01-16 Paper

DOI: 10.1039/C3CP44528C

A red-emissive aminobenzopyrano-xanthene dye: elucidation of fluorescence emission mechanisms in solution and in the aggregate state

Shinichiro Kamino, Miho Murakami, Asana Tatsumi, Noriyuki Nagaoka, Yoshinao Shirasaki, Keiko Watanabe, Kengo Yoshida, Jun Horigome, Seiji Komeda

2012-12-05 Paper

DOI: 10.1039/C2CP43503A

You might also like

Compound Q&A

What is 3-Fluoro-2-methylbenzylamine (CAS: 771573-36-5)?

3-Fluoro-2-methylbenzylamine is an organic compound with the CAS number 771573-3...

771573-36-53-Fluoro-2-methylben...
Compound Q&A

Is Tert-butyl 2-(oxetan-3-ylidene)acetate (CAS: 1207175-03-8) safe?

Tert-butyl 2-(oxetan-3-ylidene)acetate is considered safe for its intended uses ...

1207175-03-8Tert-butyl 2-(oxetan...
Compound Q&A

What precautions should be taken when handling 4-Acetyl-2-fluorobenzonitrile (CAS: 214760-18-6)?

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab co...

214760-18-64-Acetyl-2-fluoroben...
Compound Q&A

How is 2-Ethyl-4-methyl-1,3-thiazole (CAS: 15679-12-6) typically synthesized?

2-Ethyl-4-methyl-1,3-thiazole is commonly synthesized via the reaction of thiour...

15679-12-62-Ethyl-4-methyl-1,3...
Compound Q&A

How should 5',5''-([2,2'-Bithiophene]-5,5'-diyl)bis(([1,1':3',1''-terphenyl]-4,4''-dicarboxylic acid)) (CAS: 1227780-71-3) be stored?

This compound should be stored in a cool, dry place away from direct sunlight an...

1227780-71-35',5''''-([2,2'-Bith...
Compound Q&A

What regulatory guidelines apply to L-Lysine Acetate Salt (CAS: 52315-92-1)?

L-Lysine Acetate Salt (CAS: 52315-92-1) is subject to various regulatory guideli...

52315-92-1L-LYSINE ACETATE SAL...
Compound Q&A

Is 6-Fluoro-3-hydroxy-2-pyrazinecarboxamide (CAS: 259793-96-9) safe?

6-Fluoro-3-hydroxy-2-pyrazinecarboxamide (CAS: 259793-96-9) is generally conside...

259793-96-96-Fluoro-3-hydroxy-2...
Compound Q&A

What are the physical and chemical properties of 1,1'-Sulfonylbis(1H-imidazole) (CAS: 7189-69-7)?

1,1'-Sulfonylbis(1H-imidazole) is a crystalline solid with a molecular weight of...

7189-69-71,1'-Sulfonylbis(1H-...
Compound Q&A

What industries use 4-methyl-7-nitro-1H-indole-3-carbonitrile (CAS: 289483-82-5)?

4-Methyl-7-nitro-1H-indole-3-carbonitrile (CAS: 289483-82-5) is primarily used i...

289483-82-54-methyl-7-nitro-1H-...
Compound Q&A

How should waste containing 5-Bromo-3-indolyl-beta-galactoside (CAS: 97753-82-7) be handled?

Waste containing 5-Bromo-3-indolyl-beta-galactoside (CAS: 97753-82-7) should be ...

97753-82-75-Bromo-3-indolyl-be...

Source Journal

Reaction Chemistry & Engineering

Reaction Chemistry & Engineering
CiteScore: 0
Self-citation Rate: 8.8%
Articles per Year: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.