A metal-free aromatic cascade for the synthesis of diverse heterocycles
Literature Information
Steven C. Schlitzer, Dhanarajan Arunprasath, Katelyn G. Stevens, Indrajeet Sharma
A metal-free aromatic cascade has been developed for the synthesis of diverse heterocycles from readily accessible hydroxy/aminochalcones and acid/alkyl halides. The cascade is initiated by a base-mediated intramolecular aldol cyclization/dehydration sequence to provide a triene, which sets the stage for a 6π-electrocyclization/oxidative aromatization to access diverse heterocyclic scaffolds.
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