Highly substituted pyridinesvia tethered imine–enamine (TIE) methodology

Literature Information

Publication Date 2004-01-27
DOI 10.1039/B316107B
Impact Factor 6.222
Authors

Steven A. Raw, Richard J. K. Taylor


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Abstract

A tethered imine–enamine methodology has been developed for the direct conversion of 1,2,4-triazines into highly substituted pyridines via the inverse electron demand Diels–Alder reaction which avoids the need for a discrete aromatisation step. This TIE methodology has also been applied in one pot reaction cascades involving 1,2,4-triazines and utilising MnO2-mediated tandem oxidation processes (TOPs).

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