The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals
Literature Information
Publication Date
2019-11-28
DOI
10.1039/C9QO01203F
Impact Factor
5.281
Authors
Yu-Tuo Sun, Dong-Xing Zhu, Xiaofeng Rao
View Original
Abstract
A method for the highly enantioselective Rh-catalyzed dehydrated arylation of unprotected hemiaminals has been developed, and provided a series of chiral benzosultams bearing trifluoromethylated quaternary stereocenters in high yields with excellent enantioselectivities (up to 99% ee). The synthetic utility was further demonstrated by the facile enantioselective construction of a HIV-1 inhibitor molecule.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(3beta,22E)-Stigmasta-5,22-dien-3-yl beta-D-glucopyranoside
CAS Number:
19716-26-8
Molecular Formula:
C35H58O6
N-Methyl-2-(4-nitrophenyl)ethanamine hydrochloride (1:1)
CAS Number:
166943-39-1
Molecular Formula:
C9H13ClN2O2
2-Chloro-4-nitrophenyl 6-deoxy-alpha-L-galactopyranoside
CAS Number:
157843-41-9
Molecular Formula:
C12H14ClNO7
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