Transition-metal-free decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1H)-ones with α,α-difluoroarylacetic acids
Literature Information
Publication Date
2019-02-27
DOI
10.1039/C9QO00105K
Impact Factor
5.281
Authors
Jinwei Yuan, Junhao Fu, Guoyong Pan, Zhengwang Wang, Liangru Yang, Yongmei Xiao, Pu Mao, Xiangmin Zhang
View Original
Abstract
A facile transition-metal-free decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with quinoxalin-2(1H)-ones has been developed. This methodology provided a highly attractive approach to synthesize a series of difluoroarylmethylated quinoxalin-2(1H)-ones that contain various functional groups in moderate to good yields under mild conditions. Moreover, experimental studies reveal that the CF2 group of α,α-difluoroarylacetic acids plays a vital role in this transformation.
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Source Journal
Organic Chemistry Frontiers
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7.8
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